Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, India.
Truhlsen Eye Institute, University of Nebraska Medical Centre, Omaha, NE, USA.
Indian J Ophthalmol. 2024 May 1;72(5):637-647. doi: 10.4103/IJO.IJO_1346_23. Epub 2024 Apr 22.
Ocular symptoms can be the presenting manifestation of Takayasu arteritis (TA) or could be indicative of disease reactivation. A review of published literature related to posterior segment manifestations of TA by using the keywords "Takayasu arteritis," "ophthalmic manifestations," "retina," "retinopathy," "ocular," "optic nerve," and "optic neuropathy" was performed. In total, 62 case reports and 12 case series were included. The majority of the articles were from Asia (n = 47, 64%). Females outnumbered males in the ratio of 7:1. The mean age of patients was 33 years (range: 8-78 years, SD: 13.5 years). In 58% (n = 41 out of 71) cases, ocular symptoms were the presenting manifestation of the underlying disease. Hypotensive retinopathy was found in 70% of eyes, and hypertensive retinopathy was found in 27%. The mean presenting visual acuity (VA) was +1.03 logMAR (range: -0.12 to 3, SD: 1.07), and at the final follow-up was +1.02 logMAR (range: -0.12 to 3, SD 1.17). VA improved in 34% (n = 29/86), remained stable in 45% (39/86), and worsened in 21% (18/86). The mean follow-up was 9 months (range: 0.5-204, SD: 16 months).
眼部症状可作为 Takayasu 动脉炎 (TA) 的首发表现，也可能提示疾病复发。使用关键词“Takayasu 动脉炎”、“眼部表现”、“视网膜”、“视网膜病变”、“眼部”、“视神经”和“视神经病变”，对 TA 后部表现的已发表文献进行了回顾。共纳入 62 例病例报告和 12 例病例系列。大多数文章来自亚洲（n = 47，64%）。女性与男性的比例为 7:1。患者的平均年龄为 33 岁（范围：8-78 岁，SD：13.5 岁）。在 58%（n = 41/71）的病例中，眼部症状是潜在疾病的首发表现。低血压性视网膜病变占 70%，高血压性视网膜病变占 27%。平均首发视力（VA）为+1.03 logMAR（范围：-0.12 至 3，SD：1.07），最终随访时为+1.02 logMAR（范围：-0.12 至 3，SD 1.17）。34%（n = 29/86）的 VA 改善，45%（39/86）的 VA 稳定，21%（18/86）的 VA 恶化。平均随访时间为 9 个月（范围：0.5-204，SD：16 个月）。
