Department of Life and Consumer Science, College of Agriculture and Environmental Sciences, University of South Africa, Florida Campus, Roodepoort, South Africa.
Nutr Diabetes. 2024 Apr 22;14(1):22. doi: 10.1038/s41387-024-00282-6.
The beneficial effects of folate have been observed under different conditions, but the available evidence on inflammation and reduction of cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM) is limited. The study aimed to explore the effects of folate on inflammation and homocysteine amongst individuals with T2DM.
PubMed, Scopus, and Cochrane Library were used to search for evidence. A random-effect model meta-analysis through Review Manager (version 5.4) and metaHun was performed. Results were reported as standardized mean differences (SMD) and 95% confidence intervals graphically using forest and funnel plots.
Data from 9 trials with 426 patients living with T2DM were analyzed. Folic acid supplementation significantly revealed a large effect size on homocysteine levels compared to placebo, SMD = -1.53, 95%CI (-2.14,-0.93), p < 0.05. Additionally, we observed a medium marginal effect size on C-reactive protein (SMD = -0.68, 95%CI (-1.34, -0.01), p = 0.05). However, no significant effect on tumor necrosis factor-α (SMD = -0.86, 95%CI (-2.65, 0.93), p = 0.34), and interleukin-6 (SMD = -0.04, 95%CI (-1.08, 1.01), p = 0.95) was observed.
Evidence analyzed in this study suggests that folic acid supplementation in T2DM reduces homocysteine and may mitigate CVDs. However, its effect on inflammation is inconclusive.
叶酸在不同情况下都显示出有益的效果，但在 2 型糖尿病（T2DM）中关于炎症和减少心血管疾病（CVD）的证据有限。本研究旨在探讨叶酸对 T2DM 患者炎症和同型半胱氨酸的影响。
使用 PubMed、Scopus 和 Cochrane Library 搜索证据。通过 Review Manager（版本 5.4）和 metaHun 进行随机效应模型荟萃分析。结果以标准化均数差（SMD）和森林图和漏斗图表示的 95%置信区间图形呈现。
分析了 9 项涉及 426 名 T2DM 患者的试验数据。与安慰剂相比，叶酸补充剂显著降低同型半胱氨酸水平，SMD=-1.53，95%CI（-2.14，-0.93），p<0.05。此外，我们观察到 C-反应蛋白的中等边际效应大小（SMD=-0.68，95%CI（-1.34，-0.01），p=0.05）。然而，肿瘤坏死因子-α（SMD=-0.86，95%CI（-2.65，0.93），p=0.34）和白细胞介素-6（SMD=-0.04，95%CI（-1.08，1.01），p=0.95）的作用没有显著影响。
本研究分析的证据表明，T2DM 患者补充叶酸可降低同型半胱氨酸，可能减轻 CVD。然而，其对炎症的影响尚不确定。
