超重或肥胖患者血清叶酸水平与2型糖尿病之间的关联：一项回顾性研究

Association Between Serum Folic Acid Levels and Type 2 Diabetes Mellitus in Overweight or Obese Patients: A Retrospective Study.

作者信息

Dai Yaji, Guo Mingfei, Xiong Jianglei, Jiang Lei

机构信息

Department of Pharmacy, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, People's Republic of China.

Department of Scientific Research, The First Affiliated Hospital of Anhui Medical University, Anhui Public Health Clinical Center, Hefei, Anhui, People's Republic of China.

出版信息

Diabetes Metab Syndr Obes. 2025 Jul 15;18:2361-2367. doi: 10.2147/DMSO.S521273. eCollection 2025.

DOI:10.2147/DMSO.S521273

PMID:40687904

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12275910/

Abstract

PURPOSE

The relationship between folic acid (FA) levels and type 2 diabetes mellitus (T2DM) with overweight or obesity remains uncertain. This study aimed to further investigate the relationship between them.

METHODS

A retrospective study was conducted on 149 patients, comprising 64 patients with T2DM and normal weight and 85 patients with T2DM and overweight or obese status.

RESULTS

Our findings revealed significantly lower levels of FA and neutrophil-to-lymphocyte ratio (NLR) in overweight/obese T2DM patients compared to their normal-BMI counterparts (P < 0.001). The overweight/obese cohort exhibited elevated metabolic parameters, including fasting C-peptide, serum uric acid, total cholesterol (TC), triglycerides (TG), and very low-density lipoprotein cholesterol (VLDL-C) levels (P < 0.05). Notably, correlation analysis demonstrated a significant positive association between FA levels and both age (r = 0.341, P < 0.001), diabetes duration (r = 0.278, P = 0.001), and NLR (r = 0.212, P = 0.009). Conversely, inverse correlations were observed between FA levels and C-peptide (r = -0.240, P = 0.004), TG (r = -0.254, P < 0.001), and VLDL-C (r = -0.271, P = 0.001).

CONCLUSION

This research found that FA levels were significantly associated with T2DM in individuals who were overweight or obese.

摘要

目的

叶酸（FA）水平与超重或肥胖的2型糖尿病（T2DM）之间的关系仍不明确。本研究旨在进一步探讨它们之间的关系。

方法

对149例患者进行回顾性研究，其中包括64例体重正常的T2DM患者和85例超重或肥胖的T2DM患者。

结果

我们的研究结果显示，与体重指数正常的T2DM患者相比，超重/肥胖的T2DM患者的FA水平和中性粒细胞与淋巴细胞比值（NLR）显著降低（P < 0.001）。超重/肥胖队列的代谢参数升高，包括空腹C肽、血清尿酸、总胆固醇（TC）、甘油三酯（TG）和极低密度脂蛋白胆固醇（VLDL-C）水平（P < 0.05）。值得注意的是，相关性分析表明FA水平与年龄（r = 0.341，P < 0.001）、糖尿病病程（r = 0.278，P = 0.001）和NLR（r = 0.212，P = 0.009）均呈显著正相关。相反，FA水平与C肽（r = -0.240，P = 0.004）、TG（r = -0.254，P < 0.001）和VLDL-C（r = -0.271，P = 0.001）呈负相关。