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Exploring potential impacts of pregnancy-related maternal immune activation and extracellular vesicles on immune alterations observed in autism spectrum disorder.探索妊娠相关的母体免疫激活和细胞外囊泡对自闭症谱系障碍中观察到的免疫改变的潜在影响。
Heliyon. 2023 Apr 29;9(5):e15593. doi: 10.1016/j.heliyon.2023.e15593. eCollection 2023 May.
3
Perinatal Factors and Emotional, Cognitive, and Behavioral Dysregulation in Childhood and Adolescence.围产期因素与儿童和青少年时期的情绪、认知和行为失调。
J Am Acad Child Adolesc Psychiatry. 2023 Dec;62(12):1351-1362. doi: 10.1016/j.jaac.2023.05.010. Epub 2023 May 17.
4
Rates of maternal weight gain over the course of pregnancy and offspring risk of neurodevelopmental disorders.孕期体重增加速度与后代神经发育障碍风险的关系。
BMC Med. 2023 Mar 23;21(1):108. doi: 10.1186/s12916-023-02799-6.
5
Effects of parental overweight and obesity on offspring's mental health: A meta-analysis of observational studies.父母超重和肥胖对后代心理健康的影响：观察性研究的荟萃分析。
PLoS One. 2022 Dec 22;17(12):e0276469. doi: 10.1371/journal.pone.0276469. eCollection 2022.
6
Role of Excessive Weight Gain During Gestation in the Risk of ADHD in Offspring of Women With Gestational Diabetes.妊娠期间体重过度增加与妊娠糖尿病女性后代发生 ADHD 的风险的关系。
J Clin Endocrinol Metab. 2022 Sep 28;107(10):e4203-e4211. doi: 10.1210/clinem/dgac483.
7
Maternal obesity, diabetes, preeclampsia, and asthma during pregnancy and likelihood of autism spectrum disorder with gastrointestinal disturbances in offspring.母亲在怀孕期间肥胖、糖尿病、先兆子痫和哮喘与后代胃肠道紊乱自闭症谱系障碍的可能性。
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Maternal pre-pregnancy BMI and offspring hyperactivity-inattention trajectories from 3 to 8 years in the EDEN birth cohort study.在EDEN出生队列研究中，母亲孕前体重指数与3至8岁后代多动-注意力不集中轨迹的关系。
Eur Child Adolesc Psychiatry. 2023 Oct;32(10):2057-2065. doi: 10.1007/s00787-022-02047-x. Epub 2022 Jul 19.
9
Multigenerational transmission of obesity: A systematic review and meta-analysis.肥胖的多代传递：一项系统评价与荟萃分析。
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Transgenerational effects of obesogenic diets in rodents: A meta-analysis.致肥胖饮食对啮齿动物的跨代影响：一项荟萃分析。
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母亲体重过重对后代神经精神疾病风险的影响——临床研究的叙述性综述。

The impact of excessive maternal weight on the risk of neuropsychiatric disorders in offspring-a narrative review of clinical studies.

机构信息

Department of Toxicology, Jagiellonian University Medical College, Medyczna 9, 30-688, Kraków, Poland.

Department of Psychiatry, Jagiellonian University Medical College, Kopernika 21a, 31-500, Kraków, Poland.

出版信息

Pharmacol Rep. 2024 Jun;76(3):452-462. doi: 10.1007/s43440-024-00598-1. Epub 2024 Apr 22.

DOI:10.1007/s43440-024-00598-1
PMID:38649593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11126479/
Abstract

The global prevalence of overweight and obesity is a significant public health concern that also largely affects women of childbearing age. Human epidemiological studies indicate that prenatal exposure to excessive maternal weight or excessive gestational weight gain is linked to various neurodevelopmental disorders in children, including attention deficit hyperactivity disorder, autism spectrum disorder, internalizing and externalizing problems, schizophrenia, and cognitive/intellectual impairment. Considering that inadequate maternal body mass can induce serious disorders in offspring, it is important to increase efforts to prevent such outcomes. In this paper, we review human studies linking excessive maternal weight and the occurrence of mental disorders in children.

摘要

全球超重和肥胖的流行是一个重大的公共卫生关注点，也在很大程度上影响着育龄妇女。人类流行病学研究表明，孕妇体重过重或孕期体重过度增加与儿童的各种神经发育障碍有关，包括注意缺陷多动障碍、自闭症谱系障碍、内化和外化问题、精神分裂症以及认知/智力障碍。考虑到母体体重不足会导致后代出现严重的疾病，因此，应该加大努力来预防这些后果。本文综述了与孕妇体重过重和儿童精神障碍发生相关的人类研究。