Kanmiki Edmund W, Fatima Yaqoot, Mamun Abdullah A
Institute for Social Science Research, The University of Queensland, Indooroopilly, Queensland, Australia.
ARC Centre of Excellence for Children and Families over the Life Course (The Life Course Centre), The University of Queensland, Indooroopilly, Queensland, Australia.
Obes Rev. 2022 Mar;23(3):e13405. doi: 10.1111/obr.13405. Epub 2021 Dec 30.
There is a strong link between parental and offspring obesity status. However, the state of epidemiological evidence on multigenerational transmission of overweight/obesity, such as from grandparents to grandchildren, is relatively unknown. This systematic review collates and appraises existing evidence on multigenerational transmission of overweight/obesity and uses meta-analytic estimates for quantitative synthesis. Six electronic databases were searched for publications reporting the relationship between grandparents and their grandchildren overweight/obesity status. A total of 25 studies from 17 countries with a combined population of 238,771 study participants met the inclusion criteria. About 60% (15) of the reviewed studies reported a positive association between grandparent-grandchild (GP-GC) overweight/obesity, out of which 11 were statistically significant. Seven studies reported odds ratios of GP-GC overweight/obesity associations and were included in the meta-analysis. The pooled estimates showed a significant GP-GC association in overweight/obesity status (odds ratio [OR]: 1.79, 95% confidence interval [CI]: 1.01-2.57). Thus, the current research evidence shows that grandchildren's overweight/obesity status is associated with their grandparents' overweight/obesity status, indicating a multigenerational transmission of obesity. However, more studies, especially from developing countries, are required to assess the robustness of these findings. Future studies should also focus on the mechanisms through which this transmission occurs.
父母与子女的肥胖状况之间存在紧密联系。然而，关于超重/肥胖多代传递（如从祖父母到孙辈）的流行病学证据状况相对未知。本系统综述整理并评估了关于超重/肥胖多代传递的现有证据，并使用荟萃分析估计进行定量综合。检索了六个电子数据库，以查找报告祖父母与其孙辈超重/肥胖状况之间关系的出版物。来自17个国家的总共25项研究，研究参与者总数为238,771人，符合纳入标准。约60%（15项）的综述研究报告了祖父母与孙辈（GP-GC）超重/肥胖之间存在正相关，其中11项具有统计学意义。七项研究报告了GP-GC超重/肥胖关联的比值比，并被纳入荟萃分析。汇总估计显示，在超重/肥胖状况方面，GP-GC之间存在显著关联（比值比[OR]：1.79，95%置信区间[CI]：1.01 - 2.57）。因此，当前的研究证据表明，孙辈的超重/肥胖状况与其祖父母的超重/肥胖状况相关，表明肥胖存在多代传递。然而，需要更多研究，尤其是来自发展中国家的研究，来评估这些发现的稳健性。未来的研究还应关注这种传递发生的机制。
