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用于治疗应用的 PDX 模型：用于生成和筛选源自人类的 B 细胞淋巴瘤。

PDX Models in Theranostic Applications: Generation and Screening for B Cell Lymphoma of Human Origin.

机构信息

Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY, USA.

出版信息

Mol Imaging Biol. 2024 Aug;26(4):569-576. doi: 10.1007/s11307-024-01917-x. Epub 2024 Apr 22.

DOI:10.1007/s11307-024-01917-x
PMID:38649626
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11577570/
Abstract

This MIB guide briefly summarizes the generation of patient-derived xenografts (PDXs) and highlights the importance of validating PDX models for the presence of B cell lymphoma of human origin before their use in radiotheranostic applications. The use of this protocol will allow researchers to learn different methods for screening PDX models for Epstein-Barr virus (EBV)-infected B cell lymphoma.

摘要

本 MIB 指南简要总结了患者来源异种移植物（PDX）的生成，并强调了在将 PDX 模型用于放射性治疗应用之前验证其是否存在人源 B 细胞淋巴瘤的重要性。使用本方案将使研究人员能够了解用于筛选 PDX 模型中是否存在 EBV 感染的 B 细胞淋巴瘤的不同方法。

相似文献

[1]
PDX Models in Theranostic Applications: Generation and Screening for B Cell Lymphoma of Human Origin.

Mol Imaging Biol. 2024-8

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
[Transformation of patient-derived tumor xenografts into lymphomas: characteristics, influence factors and precautions].

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[10]
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引用本文的文献

[1]
MIB guides: [Zr]Zr-DFO-trastuzumab and [Cu]Cu-NOTA-Trastuzumab for Preclinical Cancer Imaging.

Mol Imaging Biol. 2025-6-26

本文引用的文献

[1]
Patient-derived xenograft models in cancer therapy: technologies and applications.

Signal Transduct Target Ther. 2023-4-12

[2]
Statins enhance the efficacy of HER2-targeting radioligand therapy in drug-resistant gastric cancers.

Proc Natl Acad Sci U S A. 2023-4-4

[3]
Development and Characterization of Nanobody-Derived CD47 Theranostic Pairs in Solid Tumors.

Research (Wash D C). 2023

[4]
Patient-derived xenograft (PDX) models, applications and challenges in cancer research.

J Transl Med. 2022-5-10

[5]
Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer.

Nat Commun. 2022-5-9

[6]
Degenerative Myelopathy and Neuropathy in NOD./SzJ (NSG) Mice Caused by Lactate Dehydrogenase-Elevating Virus (LDV).

Toxicol Pathol. 2022-4

[7]
Defining and Targeting Esophagogastric Cancer Genomic Subsets With Patient-Derived Xenografts.

JCO Precis Oncol. 2022-2

[8]
Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low Toxicity.

Clin Cancer Res. 2022-4-1

[9]
Patient-Derived Xenografts of High-Grade Serous Ovarian Cancer Subtype as a Powerful Tool in Pre-Clinical Research.

Cancers (Basel). 2021-12-15

[10]
Naturally Acquired Mouse Kidney Parvovirus Infection Produces a Persistent Interstitial Nephritis in Immunocompetent Laboratory Mice.

Vet Pathol. 2020-11

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