Matsudaira T, Kogo H, Aizawa Y, Satoh T
J Pharmacobiodyn. 1985 Jul;8(7):539-48. doi: 10.1248/bpb1978.8.539.
The effect of gonadectomy on the antihypertensive action of pindolol in male spontaneously hypertensive rats (SHR) was investigated. And we also examined the relationship between the antihypertensive effect of this drug and the renal prostaglandin E2 (PGE2) level. In gonadectomized SHR, the reduction of blood pressure was not observed by the oral administration of pindolol, although the drug exhibited a marked antihypertensive activity in sham operated SHR. Urinary PGE2 in sham operated SHR was increased following the administration of pindolol, but not in gonadectomized SHR. Similar results were obtained in the experiments using Wistar rats. The PG synthesis inhibition induced by indomethacin suppressed the antihypertensive action of pindolol. Results in the present study suggest that renal PGs, particularly PGE2, are involved in the antihypertensive mechanism of pindolol, and that male gonad takes part in the regulation of the stimulation of the renal PGE2 producing system induced by pindolol.
研究了去势对雄性自发性高血压大鼠（SHR）中吲哚洛尔降压作用的影响。并且我们还研究了该药物的降压效果与肾前列腺素E2（PGE2）水平之间的关系。在去势的SHR中，口服吲哚洛尔未观察到血压降低，尽管该药物在假手术的SHR中表现出显著的降压活性。假手术的SHR在给予吲哚洛尔后尿PGE2增加，但去势的SHR中未增加。在使用Wistar大鼠的实验中也获得了类似的结果。吲哚美辛诱导的PG合成抑制抑制了吲哚洛尔的降压作用。本研究结果表明，肾PGs，特别是PGE2，参与了吲哚洛尔的降压机制，并且雄性性腺参与了对吲哚洛尔诱导的肾PGE2产生系统刺激的调节。
