Tungsattayathitthan Usanee, Jenjanya Sukanda, Choopong Pitipol, Sanphan Wilawan, Tesavibul Nattaporn, Boonsopon Sutasinee
Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, 10700, Bangkoknoi, Bangkok, Thailand.
BMC Ophthalmol. 2024 Apr 22;24(1):181. doi: 10.1186/s12886-024-03447-0.
To determine the prevalence, clinical characteristics, and independent predictors of uveitic macular edema (UME) in patients with intermediate, posterior and panuveitis.
We retrospectively reviewed the records of patients with intermediate, posterior, and panuveitis who underwent macular assessment using optical coherence tomography between January 2015 and February 2020. The prevalence of UME and clinical characteristics of the patients were described. Predictors of UME were identified using multivariate regression analysis.
A total of 349 patients were included. The mean age was 41 years, female: male ratio was 1.3:1. The prevalence of UME was 51.9%. UME was found in 33.9%, 56.9%, and 54.1% of the intermediate, posterior, and panuveitis cases, respectively. Among patients with UME, 47% had infectious uveitis, 32.6% had idiopathic uveitis, and 20.4% had immune-mediated uveitis. Diffuse macular edema was the most frequently observed pattern (36.5%). Multivariate analysis showed that factors independently associated with UME included age at uveitis onset (adjusted odds ratio [aOR] 1.01, 95% confidence interval [CI] 1.00-1.03, P = 0.036), PU and panuveitis compared with intermediate uveitis (aOR 2.09, 95% CI 1.14-3.86, P = 0.018), and infectious uveitis compared with noninfectious uveitis (aOR 2.13, 95% CI 1.34-3.37, P = 0.001).
Increasing age at uveitis onset, posterior/panuveitis, and infectious etiology are predictive factors for UME in patients with intermediate, posterior and panuveitis.
确定中间葡萄膜炎、后葡萄膜炎和全葡萄膜炎患者中葡萄膜炎性黄斑水肿（UME）的患病率、临床特征及独立预测因素。
我们回顾性分析了2015年1月至2020年2月间接受光学相干断层扫描进行黄斑评估的中间葡萄膜炎、后葡萄膜炎和全葡萄膜炎患者的记录。描述了UME的患病率及患者的临床特征。使用多因素回归分析确定UME的预测因素。
共纳入349例患者。平均年龄为41岁，女性与男性比例为1.3:1。UME的患病率为51.9%。在中间葡萄膜炎、后葡萄膜炎和全葡萄膜炎病例中，UME的发生率分别为33.9%、56.9%和54.1%。在UME患者中，47%患有感染性葡萄膜炎，32.6%患有特发性葡萄膜炎，20.4%患有免疫介导性葡萄膜炎。弥漫性黄斑水肿是最常见的类型（36.5%）。多因素分析显示，与UME独立相关的因素包括葡萄膜炎发病年龄（调整优势比[aOR]1.01，95%置信区间[CI]1.00 - 1.03，P = 0.036），与中间葡萄膜炎相比，后葡萄膜炎和全葡萄膜炎（aOR 2.09，95% CI 1.14 - 3.86，P = 0.018），以及与非感染性葡萄膜炎相比，感染性葡萄膜炎（aOR 2.13，95% CI 1.34 - 3.37，P = 0.001）。
葡萄膜炎发病年龄增加、后葡萄膜炎/全葡萄膜炎以及感染性病因是中间葡萄膜炎、后葡萄膜炎和全葡萄膜炎患者UME的预测因素。
