Eustis S L, Boorman G A
J Natl Cancer Inst. 1985 Dec;75(6):1067-73.
A microscopic review of pancreata from corn oil vehicle control and untreated control F344/N male rats in thirty-seven 2-year carcinogenesis studies was conducted to determine the extent and strength of the association of proliferative exocrine pancreatic lesions with corn oil gavage. The incidence of focal basophilic cellular change was similar in both untreated and vehicle control groups and was unrelated to corn oil gavage. The overall incidences of focal acinar hyperplasia and acinar adenoma were about five times greater in male rats that received the corn oil than in untreated rats (12.6 and 4.9% vs. 2.6 and 0.9%). This association was not consistent for each study group of vehicle controls. Over one-third (7/20) of the vehicle control groups had incidences of hyperplasia and adenoma no greater than the average rate for untreated male rats. There was no relationship between incidences of proliferative acinar lesions and the animal laboratory, the animal source, and the brand, lot, or peroxide level of the corn oil. The incidences of focal acinar hyperplasia and acinar adenoma were related to maximum mean body weights attained by the groups during the course of the study.
在37项为期2年的致癌性研究中，对玉米油载体对照组和未处理对照组的F344/N雄性大鼠的胰腺进行了显微镜检查，以确定增殖性外分泌胰腺病变与玉米油灌胃之间关联的程度和强度。未处理组和载体对照组的局灶性嗜碱性细胞变化发生率相似，且与玉米油灌胃无关。接受玉米油的雄性大鼠的局灶性腺泡增生和腺泡腺瘤的总体发生率比未处理大鼠高约五倍（分别为12.6%和4.9%，对比2.6%和0.9%）。这种关联在载体对照组的每个研究组中并不一致。超过三分之一（7/20）的载体对照组的增生和腺瘤发生率不高于未处理雄性大鼠的平均发生率。增殖性腺泡病变的发生率与动物实验室、动物来源以及玉米油的品牌、批次或过氧化物水平之间没有关系。局灶性腺泡增生和腺泡腺瘤的发生率与研究过程中各组达到的最大平均体重有关。
