Jiao Liwu, Kang Huicong, Geng Yumei, Liu Xuyang, Wang Mengying, Shu Kai
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Front Aging Neurosci. 2024 Apr 8;16:1376764. doi: 10.3389/fnagi.2024.1376764. eCollection 2024.
As a crucial component of the cerebral cholinergic system and the Papez circuit in the basal forebrain, dysfunction of the nucleus basalis of Meynert (NBM) is associated with various neurodegenerative disorders. However, no drugs, including existing cholinesterase inhibitors, have been shown to reverse this dysfunction. Due to advancements in neuromodulation technology, researchers are exploring the use of deep brain stimulation (DBS) therapy targeting the NBM (NBM-DBS) to treat mental and neurological disorders as well as the related mechanisms. Herein, we provided an update on the research progress on cognition-related neural network oscillations and complex anatomical and projective relationships between the NBM and other cognitive structures and circuits. Furthermore, we reviewed previous animal studies of NBM lesions, NBM-DBS models, and clinical case studies to summarize the important functions of the NBM in neuromodulation. In addition to elucidating the mechanism of the NBM neural network, future research should focus on to other types of neurons in the NBM, despite the fact that cholinergic neurons are still the key target for cell type-specific activation by DBS.
作为大脑胆碱能系统和基底前脑帕佩兹环路的关键组成部分，梅纳特基底核（NBM）功能障碍与多种神经退行性疾病相关。然而，包括现有胆碱酯酶抑制剂在内，尚无药物被证明能逆转这种功能障碍。由于神经调节技术的进步，研究人员正在探索针对NBM的深部脑刺激（DBS）疗法（NBM-DBS）来治疗精神和神经疾病及其相关机制。在此，我们提供了关于认知相关神经网络振荡以及NBM与其他认知结构和环路之间复杂解剖和投射关系的研究进展的最新情况。此外，我们回顾了以往关于NBM损伤、NBM-DBS模型的动物研究以及临床病例研究，以总结NBM在神经调节中的重要功能。除了阐明NBM神经网络的机制外，未来的研究尽管胆碱能神经元仍是DBS进行细胞类型特异性激活的关键靶点，但应关注NBM中的其他类型神经元。
