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聚肌胞苷酸（Poly I:C）比氢氧化铝佐剂在小鼠中引发更广泛和更强的针对疟原虫环子孢子蛋白疫苗的体液和细胞反应。

Poly I:C elicits broader and stronger humoral and cellular responses to a circumsporozoite protein malaria vaccine than Alhydrogel in mice.

机构信息

Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

Laboratório de Vacinas Recombinantes, Departamento de Biociências, Universidade Federal de São Paulo, Santos, Brazil.

出版信息

Front Immunol. 2024 Apr 8;15:1331474. doi: 10.3389/fimmu.2024.1331474. eCollection 2024.

DOI:10.3389/fimmu.2024.1331474
PMID:38650939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11033515/
Abstract

Malaria remains a global health challenge, necessitating the development of effective vaccines. The RTS,S vaccination prevents (Pf) malaria but is ineffective against (Pv) disease. Herein, we evaluated the murine immunogenicity of a recombinant PvCSP incorporating prevalent polymorphisms, adjuvanted with Alhydrogel or Poly I:C. Both formulations induced prolonged IgG responses, with IgG1 dominance by the Alhydrogel group and high titers of all IgG isotypes by the Poly I:C counterpart. Poly I:C-adjuvanted vaccination increased splenic plasma cells, terminally-differentiated memory cells (MBCs), and precursors relative to the Alhydrogel-combined immunization. Splenic B-cells from Poly I:C-vaccinated mice revealed an antibody-secreting cell- and MBC-differentiating gene expression profile. Biological processes such as antibody folding and secretion were highlighted by the Poly I:C-adjuvanted vaccination. These findings underscore the potential of Poly I:C to strengthen immune responses against Pv malaria.

摘要

疟疾仍然是一个全球性的健康挑战，需要开发有效的疫苗。RTS,S 疫苗可预防（Pf）疟疾，但对（Pv）病无效。在此，我们评估了一种包含常见多态性的重组 PvCSP 的鼠类免疫原性，并用 Alhydrogel 或 Poly I:C 佐剂。这两种制剂都诱导了长时间的 IgG 反应，Alhydrogel 组 IgG1 占主导地位，而 Poly I:C 组所有 IgG 同型的滴度都很高。与 Alhydrogel 联合免疫相比，Poly I:C 佐剂疫苗接种增加了脾浆细胞、终末分化的记忆细胞（MBC）和前体细胞。来自 Poly I:C 疫苗接种小鼠的脾 B 细胞显示出抗体分泌细胞和 MBC 分化的基因表达谱。Poly I:C 佐剂疫苗接种突出了抗体折叠和分泌等生物学过程。这些发现强调了 Poly I:C 加强对 Pv 疟疾免疫反应的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/11033515/44cde56e5e0c/fimmu-15-1331474-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/11033515/78ebc33bf0a1/fimmu-15-1331474-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/11033515/4ded8db5b143/fimmu-15-1331474-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/11033515/abf7c0044f77/fimmu-15-1331474-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/11033515/ae4112af98d8/fimmu-15-1331474-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/11033515/44cde56e5e0c/fimmu-15-1331474-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/11033515/78ebc33bf0a1/fimmu-15-1331474-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/11033515/4ded8db5b143/fimmu-15-1331474-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/11033515/abf7c0044f77/fimmu-15-1331474-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/11033515/ae4112af98d8/fimmu-15-1331474-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e64/11033515/44cde56e5e0c/fimmu-15-1331474-g005.jpg

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