Department of Mechanics, School of Mechanical Engineering, Tianjin University, Tianjin, China.
J Biophotonics. 2024 Jun;17(6):e202400003. doi: 10.1002/jbio.202400003. Epub 2024 Apr 23.
This paper introduces a spectral analysis method for monitoring the human skin in vivo based on a combination of terahertz time-domain spectroscopy (THz-TDS) and optical coherence tomography (OCT). The method can quantitatively measure the refractive index, thickness and transmission coefficient of epidermis, and the refractive index of dermis in natural, as well as the tension condition of the skin. An optically reflective model for the multilayer structure of the skin is first established. The initial thickness of the epidermis is then measured by OCT as a known quantity for the established model. By fitting the established model to the experimentally obtained THz-TDS signals, the above parameters of the skin can be calibrated. Furthermore, the dependence of these skin parameters on the tension status are investigated. This study provides a means for terahertz technology to measure the skin in vivo.
本文提出了一种基于太赫兹时域光谱（THz-TDS）和光学相干断层扫描（OCT）技术的人体皮肤光谱分析方法。该方法可以定量测量表皮的折射率、厚度和透过率，以及真皮的折射率，以及皮肤的张力状态。首先建立了皮肤多层结构的光学反射模型，然后将 OCT 测量的表皮初始厚度作为建立模型的已知量。通过将建立的模型拟合到实验获得的太赫兹时域光谱信号，可以校准皮肤的上述参数。此外，还研究了这些皮肤参数与张力状态的关系。本研究为太赫兹技术测量活体皮肤提供了一种手段。
