Miyaoka Chika, Watanabe Masato, Nakamoto Keitaro, Yoshida Yuki, Hirata Aya, Aso Jumpei, Nunokawa Hiroki, Ishida Manabu, Honda Koujiro, Takata Saori, Saraya Takeshi, Ishii Haruyuki
Department of Respiratory Medicine, Kyorin University Faculty of Medicine, Mitaka City, Tokyo, Japan.
Immun Inflamm Dis. 2024 Apr;12(4):e1252. doi: 10.1002/iid3.1252.
We developed pulmonary emphysema and a type 2 airway inflammation overlap mouse model. The bronchoalveolar lavage (BAL) interleukin 13 (IL-13), IL-4, and IL-5 levels in the overlap model were higher than in the pulmonary emphysema model and lower than in the type 2 airway inflammation model, but IL-33 level in the lung was higher than in other models. IL-33 and interferon-γ (IFNγ) in lungs may control the severity of a type 2 airway inflammation in lung.
我们构建了肺气肿与2型气道炎症重叠的小鼠模型。重叠模型中的支气管肺泡灌洗（BAL）白细胞介素13（IL-13）、IL-4和IL-5水平高于肺气肿模型，低于2型气道炎症模型，但肺组织中的IL-33水平高于其他模型。肺组织中的IL-33和干扰素-γ（IFNγ）可能控制肺部2型气道炎症的严重程度。
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