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叉头框蛋白1在食管鳞状细胞癌中的抗癌作用的综合分析

An integrated analysis of the anticarcinogenic role of forkhead box protein 1 in oesophageal squamous cell carcinoma.

作者信息

Ye Guanzhi, Pan Gaojian, Zhu Xiaolei, Li Ning, Liu Hongming, Geng Guojun, Jiang Jie

机构信息

Department of Thoracic Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.

出版信息

J Cell Mol Med. 2024 Apr;28(8):e18294. doi: 10.1111/jcmm.18294.

DOI:10.1111/jcmm.18294
PMID:38652109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11037412/
Abstract

Forkhead box protein 1 (FOXP1) serves as a tumour promoter or suppressor depending on different cancers, but its effect in oesophageal squamous cell carcinoma has not been fully elucidated. This study investigated the role of FOXP1 in oesophageal squamous cell carcinoma through bioinformatics analysis and experimental verification. We determined through public databases that FOXP1 expresses low in oesophageal squamous cell carcinoma compared with normal tissues, while high expression of FOXP1 indicates a better prognosis. We identified potential target genes regulated by FOXP1, and explored the potential biological processes and signalling pathways involved in FOXP1 in oesophageal squamous cell carcinoma through GO and KEGG enrichment, gene co-expression analysis, and protein interaction network construction. We also analysed the correlation between FOXP1 and tumour immune infiltration levels. We further validated the inhibitory effect of FOXP1 on the proliferation of oesophageal squamous cell carcinoma cells through CCK-8, colony formation and subcutaneous tumour formation assays. This study revealed the anticarcinogenic effect of FOXP1 in oesophageal squamous cell carcinoma, which may serve as a novel biological target for the treatment of tumour.

摘要

叉头框蛋白1（FOXP1）根据不同癌症充当肿瘤促进因子或抑制因子，但其在食管鳞状细胞癌中的作用尚未完全阐明。本研究通过生物信息学分析和实验验证来探究FOXP1在食管鳞状细胞癌中的作用。我们通过公共数据库确定，与正常组织相比，FOXP1在食管鳞状细胞癌中表达较低，而FOXP1的高表达预示着较好的预后。我们鉴定了受FOXP1调控的潜在靶基因，并通过GO和KEGG富集、基因共表达分析以及蛋白质相互作用网络构建，探索了FOXP1在食管鳞状细胞癌中涉及的潜在生物学过程和信号通路。我们还分析了FOXP1与肿瘤免疫浸润水平之间的相关性。我们通过CCK-8、集落形成和皮下肿瘤形成实验进一步验证了FOXP1对食管鳞状细胞癌细胞增殖的抑制作用。本研究揭示了FOXP1在食管鳞状细胞癌中的抗癌作用，这可能成为肿瘤治疗的一个新的生物学靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/3e9344d53672/JCMM-28-e18294-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/ac9895c9f5f9/JCMM-28-e18294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/a58e22e9a510/JCMM-28-e18294-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/890ddb9fa778/JCMM-28-e18294-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/1a1294f9ae3a/JCMM-28-e18294-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/31dcfe22de62/JCMM-28-e18294-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/3e9344d53672/JCMM-28-e18294-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/ac9895c9f5f9/JCMM-28-e18294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/a58e22e9a510/JCMM-28-e18294-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/890ddb9fa778/JCMM-28-e18294-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/1a1294f9ae3a/JCMM-28-e18294-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/31dcfe22de62/JCMM-28-e18294-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6e1/11037412/3e9344d53672/JCMM-28-e18294-g002.jpg

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