Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Institute of Liver Diseases, Shuguang Hospital Affifiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Institute of Clinical Pharmacology, Shuguang Hospital Affifiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Endocrinol (Lausanne). 2023 Jan 31;14:1081500. doi: 10.3389/fendo.2023.1081500. eCollection 2023.
Abnormal glucose metabolism and lipid metabolism are common pathological processes in many metabolic diseases, such as nonalcoholic fatty liver disease (NAFLD). Many studies have shown that the forkhead box (FOX) protein subfamily FOXA has a role in regulating glucolipid metabolism and is closely related to hepatic steatosis and NAFLD. FOXA exhibits a wide range of functions ranging from the initiation steps of metabolism such as the development of the corresponding metabolic organs and the differentiation of cells, to multiple pathways of glucolipid metabolism, to end-of-life problems of metabolism such as age-related obesity. The purpose of this article is to review and discuss the currently known targets and signal transduction pathways of FOXA in glucolipid metabolism. To provide more experimental evidence and basis for further research and clinical application of FOXA in the regulation of glucolipid metabolism and the prevention and treatment of NAFLD.
异常的糖代谢和脂代谢是许多代谢性疾病（如非酒精性脂肪性肝病）的常见病理过程。许多研究表明，叉头框（FOX）蛋白亚家族 FOXA 在调节糖脂代谢中发挥作用，与肝脂肪变性和非酒精性脂肪性肝病密切相关。FOXA 表现出广泛的功能，从代谢的起始步骤，如相应代谢器官的发育和细胞的分化，到糖脂代谢的多条途径，再到代谢的生命末期问题，如与年龄相关的肥胖。本文旨在综述和讨论 FOXA 在糖脂代谢中的已知靶点和信号转导通路，为进一步研究和临床应用 FOXA 调节糖脂代谢、防治非酒精性脂肪性肝病提供更多的实验依据。
