Mikaelsen Jan Rune, Jakobsen Rune Bruhn, Røtterud Jan Harald, Randsborg Per-Henrik
Department of Orthopaedic Surgery, Akershus University Hospital, Lørenskog, Norway.
Faculty of Medicine, Institute of Clinical Medicine, Campus Ahus, University of Oslo, Lørenskog, Norway.
Arthroplast Today. 2024 Apr 16;27:101376. doi: 10.1016/j.artd.2024.101376. eCollection 2024 Jun.
There are conflicting reports in the literature regarding the risk of revision after primary total knee replacement (TKR) in obese patients. The purpose of this study was to investigate if body mass index (BMI) influences the risk of revision 3-9 years after primary TKR.
All patients undergoing a primary TKR in our institution from 2014 to 2018 were included in a retrospective study. The effect of BMI on all-cause revision was estimated in a logistic regression analysis. A directed acyclic graph was created to identify variables affecting the primary endpoint (revision). According to the directed acyclic graph, adjustment was only needed for age and smoking. However, we also included variables thought to influence the revision risk based on clinical experience and previous research. The final logistic regression analysis was therefore adjusted for age, sex, smoking status, diabetes mellitus and the American Society of Anesthesiologists classification.
One thousand fifty-nine primary TKR patients with a mean age of 68.1 (standard deviation 9.4) years were included. There were 609 (57.5%) women, and the median follow-up time was 5.6 (range 3.0-9.0) years. There were 41 (3.9%) revisions. BMI did not affect the risk of revision when adjusted for relevant covariates in a multivariate logistic regression analysis (odds ratio 0.99, 95% confidence interval 0.93-1.05, = .6).
BMI did not influence the risk of revision rate 3-9 years after TKR.
关于肥胖患者初次全膝关节置换术(TKR)后翻修风险,文献中的报道相互矛盾。本研究的目的是调查体重指数(BMI)是否会影响初次TKR术后3至9年的翻修风险。
对2014年至2018年在本机构接受初次TKR的所有患者进行回顾性研究。通过逻辑回归分析评估BMI对全因翻修的影响。创建了一个有向无环图以识别影响主要终点(翻修)的变量。根据有向无环图,仅需对年龄和吸烟进行调整。然而,我们还纳入了基于临床经验和先前研究认为会影响翻修风险的变量。因此,最终的逻辑回归分析对年龄、性别、吸烟状况、糖尿病和美国麻醉医师协会分级进行了调整。
纳入了1059例初次TKR患者,平均年龄为68.1(标准差9.4)岁。其中有609例(57.5%)女性,中位随访时间为5.6(范围3.0 - 9.0)年。有41例(3.9%)进行了翻修。在多变量逻辑回归分析中对相关协变量进行调整后,BMI并未影响翻修风险(比值比0.99,95%置信区间0.93 - 1.05,P = 0.6)。
BMI并未影响TKR术后3至9年的翻修率风险。