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肥胖对单髁膝关节置换翻修率的影响:系统评价和荟萃分析。

The effect of obesity on revision rate in unicompartmental knee arthroplasty: a systematic review and meta-analysis.

机构信息

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Windmill Road, Oxford, OX3 7LD, UK.

Medical Sciences Division, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK.

出版信息

Knee Surg Sports Traumatol Arthrosc. 2021 Oct;29(10):3467-3477. doi: 10.1007/s00167-020-06297-7. Epub 2020 Oct 16.

Abstract

The number of patients with knee osteoarthritis, the proportion that is obese and the number undergoing unicompartmental knee arthroplasty (UKA) are all increasing. The primary aim of this systematic review was to determine the effects of obesity on outcomes in UKA. A systematic review was performed using PRISMA guidelines and the primary outcome was revision rate per 100 observed component years, with a BMI of ≥ 30 used to define obesity. The MINORS criteria and OCEBM criteria were used to assess risk of bias and level of evidence, respectively. 9 studies were included in the analysis. In total there were 4621 knees that underwent UKA. The mean age in included studies was reported to be 63 years (mean range 59.5-72 years old)) and range of follow up was 2-18 years. Four studies were OCEBM level 2b and the average MINORS score was 13. The mean revision rate in obese patients (BMI > 30) was 0.33% pa (95% CI - 3.16 to 2.5) higher than in non-obese patients, however this was not statistically significant (p = 0.82). This meta-analysis concludes that there is no significant difference in outcomes between obese and non-obese patients undergoing UKA. There is currently no evidence that obesity should be considered a definite contraindication to UKA. Further studies are needed to increase the numbers in meta-analysis to explore activity levels, surgeon's operative data, implant design and perioperative complications and revision in more depth.Level of evidence Level III.

摘要

骨关节炎患者人数、肥胖患者比例以及接受单髁膝关节置换术 (UKA) 的人数都在增加。本系统评价的主要目的是确定肥胖对 UKA 结果的影响。本系统评价采用 PRISMA 指南进行,主要结局指标为每 100 个观察到的组件年的翻修率,BMI≥30 用于定义肥胖。MINORS 标准和 OCEBM 标准分别用于评估偏倚风险和证据水平。共纳入 9 项研究进行分析。共纳入 4621 例接受 UKA 的膝关节。纳入研究的平均年龄报告为 63 岁(平均范围 59.5-72 岁),随访时间为 2-18 年。有 4 项研究为 OCEBM 2b 级,平均 MINORS 评分为 13 分。肥胖患者(BMI>30)的平均翻修率为 0.33%pa(95%CI-3.16 至 2.5),高于非肥胖患者,但无统计学意义(p=0.82)。这项荟萃分析的结论是,肥胖和非肥胖患者接受 UKA 的结果没有显著差异。目前没有证据表明肥胖应被视为 UKA 的明确禁忌症。需要进一步研究来增加荟萃分析的数量,以更深入地探讨活动水平、外科医生的手术数据、植入物设计以及围手术期并发症和翻修。证据水平为 III 级。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cac/8458170/dd87dd792d18/167_2020_6297_Fig1_HTML.jpg

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