Arnalich-Montiel Francisco
Cornea Unit, Hospital Universitario Ramón y Cajal de Madrid, Madrid, Spain.
Taiwan J Ophthalmol. 2024 Mar 15;14(1):108-111. doi: 10.4103/tjo.TJO-D-23-00176. eCollection 2024 Jan-Mar.
This case report presents a unique instance of a 55-year-old male patient exhibiting features of both Terrien marginal degeneration (TMD) and Fuchs' superficial marginal keratitis. Characterized by peripheral corneal thinning vascularization, and a pseudopterygium, the patient experienced recurrent photophobia, redness, and tearing over 15 years. This case challenges the traditional distinction between TMD and Fuchs' superficial marginal keratitis, suggesting a potential common underlying disorder. Mycophenolate mofetil provided a partial response, while pseudopterygium removal led to sustained remission, emphasizing its therapeutic significance. This case highlights the first documented use of mycophenolate in TMD and supports the notion of shared vasculitic origins between TMD and Fuchs' keratitis, raising intriguing questions about targeted therapeutic interventions.
本病例报告展示了一名55岁男性患者的独特情况，该患者同时表现出泰里恩边缘性角膜变性（TMD）和富克斯表层边缘性角膜炎的特征。其特点为周边角膜变薄、血管化以及假性翼状胬肉，患者在15年中反复出现畏光、眼红和流泪症状。该病例对TMD和富克斯表层边缘性角膜炎之间的传统区分提出了挑战，提示可能存在潜在的共同基础疾病。霉酚酸酯产生了部分疗效，而切除假性翼状胬肉导致病情持续缓解，凸显了其治疗意义。本病例突出了霉酚酸酯在TMD中的首次文献记载使用，并支持TMD和富克斯角膜炎之间存在共同血管炎起源的观点，引发了关于靶向治疗干预的有趣问题。
