Soula Maxime, Messas Nour-Imène, Aridhi Slah, Urbinelli Renaud, Guyon Alice
Université Côte d'Azur, Institut Neuromod, Mod4NeuCog, France.
Sensoria Analytics, Sophia Antipolis, France.
Heliyon. 2024 Apr 4;10(8):e29127. doi: 10.1016/j.heliyon.2024.e29127. eCollection 2024 Apr 30.
Trace elements, often used as dietary supplements, are widely accessible without prescription at pharmacies. Pronutri has pioneered Nutripuncture®, a methodology that utilizes orally consumed trace elements to elicit a physiological response akin to that of acupuncture. Pronutri has empirically observed that the user's voice becomes deeper following an exclusive ingestion procedure. Given that alterations in vocal characteristics are often linked to stress, the Pronutri researchers postulated that the pills have the capacity to promptly alleviate stress upon ingestion. Nevertheless, there is a lack of scientific substantiation about the impact of these supplements on voice (or stress) indicators. The aim of this research was to determine whether there is a consistent impact of trace element ingestion on vocal characteristics, namely the fundamental frequency of the voice, as well as other physiological and psychological stress measurements. In order to achieve this objective, we have devised a unique methodology to examine this hypothesis. This involves conducting a monocentric crossover, randomized, triple-blind, placebo-controlled trial with a sample size of 43 healthy individuals. This study demonstrates that compared to placebo tablets, consuming 10 metal traces containing tablets at once is enough to cause noticeable changes in the vocal spectrum in the direction of an improvement of the voice timbre "richness", and a decrease in the occurrence of spontaneous electrodermal activity, suggesting a stress reduction. However, there were no significant changes observed in the other parameters that were tested. These parameters include vocal measures such as voice frequency F0, standard deviation from this frequency, jitter, and shimmer. Additionally, physiological measures such as respiratory rate, oxygenation and heart rate variability parameters, as well as psychological measures such as self-assessment analogic scales of anxiety, stress, muscle tension, and nervous tension, did not show any significant changes. Ultimately, our research revealed that the ingestion of 10 trace elements pills may promptly elicit a targeted impact on both vocal spectrum and electrodermal activity. Despite the limited impact, these findings warrant more research to explore the long-term effects of trace elements on voice and stress reduction.
微量元素常被用作膳食补充剂，在药店无需处方即可广泛获取。普诺特里开创了营养针刺疗法（Nutripuncture®），这是一种利用口服微量元素引发类似于针灸生理反应的方法。普诺特里通过经验观察到，在进行特定的摄入程序后，使用者的声音会变低沉。鉴于声音特征的变化通常与压力有关，普诺特里的研究人员推测这些药丸在摄入后有迅速缓解压力的能力。然而，关于这些补充剂对声音（或压力）指标的影响缺乏科学依据。本研究的目的是确定摄入微量元素对声音特征（即声音的基频）以及其他生理和心理压力测量指标是否有一致的影响。为了实现这一目标，我们设计了一种独特的方法来检验这一假设。这包括进行一项单中心交叉、随机、三盲、安慰剂对照试验，样本为43名健康个体。这项研究表明，与安慰剂片相比，一次性服用10片含金属微量元素的片剂足以使声谱产生明显变化，朝着改善声音音色“丰富度”的方向发展，并减少自发皮肤电活动的发生，这表明压力有所减轻。然而，在测试的其他参数中未观察到显著变化。这些参数包括声音测量指标，如声音频率F0、该频率的标准差、抖动和闪烁。此外，生理测量指标，如呼吸频率、氧合和心率变异性参数，以及心理测量指标，如焦虑、压力、肌肉紧张和神经紧张的自我评估模拟量表，均未显示出任何显著变化。最终，我们的研究表明，摄入10片微量元素药丸可能会迅速对声谱和皮肤电活动产生针对性影响。尽管影响有限，但这些发现值得进一步研究，以探索微量元素对声音和减轻压力的长期影响。
