The First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan City, Shandong Province, China.
Hospital of Shandong University of Traditional Chinese Medicine, Jinan City, Shandong Province, China.
J Cardiovasc Pharmacol Ther. 2024 Jan-Dec;29:10742484241248046. doi: 10.1177/10742484241248046.
Atherosclerosis is now widely considered to be a chronic inflammatory disease, with increasing evidence suggesting that lipid alone is not the main factor contributing to its development. Rather, atherosclerotic plaques contain a significant amount of inflammatory cells, characterized by the accumulation of monocytes and lymphocytes on the vessel wall. This suggests that inflammation may play a crucial role in the occurrence and progression of atherosclerosis. As research deepens, other pathological factors have also been found to influence the development of the disease. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is a recently discovered target of inflammation that has gained attention in recent years. Numerous studies have provided evidence for the causal role of this pathway in atherosclerosis, and its downstream signaling factors play a significant role in this process. This brief review aims to explore the crucial role of the JAK/STAT pathway and its representative downstream signaling factors in the development of atherosclerosis. It provides a new theoretical basis for clinically affecting the development of atherosclerosis by interfering with the JAK/STAT signaling pathway.
动脉粥样硬化现在被广泛认为是一种慢性炎症性疾病，越来越多的证据表明，脂质本身并不是导致其发展的主要因素。相反，粥样硬化斑块含有大量的炎症细胞，其特征是单核细胞和淋巴细胞在血管壁上的积累。这表明炎症可能在动脉粥样硬化的发生和发展中起关键作用。随着研究的深入，其他病理因素也被发现会影响疾病的发展。Janus 激酶/信号转导和转录激活因子（JAK/STAT）途径是最近发现的炎症靶点，近年来受到关注。许多研究为该途径在动脉粥样硬化中的因果作用提供了证据，其下游信号因子在这一过程中起着重要作用。本综述旨在探讨 JAK/STAT 途径及其代表性下游信号因子在动脉粥样硬化发展中的关键作用，为临床上通过干扰 JAK/STAT 信号通路来影响动脉粥样硬化的发展提供新的理论依据。
