Shao Xinyi, Huang Kun, Chen Aijun, Liu Chuan, Xiong Jianxia, Pan Yun, Chen Xiaoli, Wang Ping
Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
J Int Med Res. 2024 Apr;52(4):3000605241239856. doi: 10.1177/03000605241239856.
Psoriasis is a chronic inflammatory skin disease. It is associated with many autoimmune diseases such as rheumatoid arthritis, Crohn's disease and thyroid diseases. Graves' disease (GD) is a common organ-specific autoimmune disease characterized by diffuse goitre and thyrotoxicosis. Management of psoriasis patients with GD is challenging. This current report presents the case of a 34-year-old female patient with refractory psoriasis with GD who was hospitalized for drug eruption and then experienced new-onset erythema and scaling following treatment with adalimumab and secukinumab. Despite the sequential move to phototherapy, tofacitinib and ustekinumab, the erythema and scaling continued unabated and exacerbated. Finally, switching to guselkumab resulted in the psoriasis lesions significantly improving. These findings suggest that guselkumab might be an effective treatment option for refractory psoriasis combined with GD.
银屑病是一种慢性炎症性皮肤病。它与许多自身免疫性疾病相关，如类风湿性关节炎、克罗恩病和甲状腺疾病。格雷夫斯病（GD）是一种常见的器官特异性自身免疫性疾病，其特征为弥漫性甲状腺肿和甲状腺毒症。对患有GD的银屑病患者进行管理具有挑战性。本报告介绍了一名34岁患有难治性银屑病合并GD的女性患者的病例，该患者因药物疹住院，在接受阿达木单抗和司库奇尤单抗治疗后出现新发红斑和鳞屑。尽管先后转向光疗、托法替布和乌司奴单抗治疗，但红斑和鳞屑持续不减且加重。最后，改用古塞库单抗后银屑病皮损显著改善。这些发现表明，古塞库单抗可能是治疗难治性银屑病合并GD的一种有效选择。
