食物剥夺和3-巯基吡啶甲酸对糖原贮积病（gsd/gsd）大鼠的体内影响。
Effects in vivo of food deprivation and 3-mercaptopicolinate in the glycogen-storage-disease (gsd/gsd) rat.
作者信息
Clark D G, Brinkman M, Neville S D, Haynes W D
出版信息
Biochem J. 1985 Nov 1;231(3):755-9. doi: 10.1042/bj2310755.
Abstract
Intraperitoneal injection of 3-mercaptopicolinate into 24 h-food-deprived 27-week-old female control (GSD/GSD) rats lowered the concentration of circulating glucose by 66%, but glycerol and lactate concentrations were increased up to 3- and 4-fold respectively. In phosphorylase b kinase-deficient (gsd/gsd) rats the corresponding changes for blood glucose, lactate and glycerol were half those observed in the controls. Although the concentration of liver glycogen (approx. 12%, w/w) in the gsd/gsd rats was not altered during food deprivation, total hepatic glycogen was decreased by 17%. It is suggested that the gradual breakdown of the extensive hepatic glycogen stores during starvation assists in the maintenance of normoglycaemia in the gsd/gsd rat.
摘要
给禁食24小时的27周龄雌性对照（GSD/GSD）大鼠腹腔注射3-巯基吡啶甲酸盐后，循环葡萄糖浓度降低了66%，但甘油和乳酸浓度分别增加了3倍和4倍。在磷酸化酶b激酶缺陷（gsd/gsd）大鼠中，血糖、乳酸和甘油的相应变化仅为对照组的一半。尽管gsd/gsd大鼠在禁食期间肝糖原浓度（约12%，w/w）未发生改变，但肝脏总糖原减少了17%。这表明饥饿期间肝脏大量糖原储备的逐渐分解有助于维持gsd/gsd大鼠的正常血糖水平。
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