Fei Sun, Liu Min, Shanshan Hu, Xie Ruijie, Danni Wu, Ningying Zhou
Wuxi Medical College of Jiangnan University, Wuxi, China.
Wuxi Maternity and Child Health Care Hospital, Wuxi, China.
Endocr Connect. 2024 May 20;13(6). doi: 10.1530/EC-23-0450. Print 2024 Jun 1.
Depression has become a multifaceted global health issue, with complex connections to obesity. Weight-adjusted-waist index (WWI) can effectively evaluate central obesity, but the relationship between WWI and depression has not been well studied. The study aims to investigate the potential correlation between these two health parameters.
According to the data from National Health and Nutrition Examination Survey, this cross-sectional study used multiple regression analysis, subgroup analysis, and smooth curve fitting to explore the relationship between WWI and depression. The assessment ability of WWI was evaluated and compared to other obesity indicators using the receiver operating characteristic (ROC) curve.
This study analyzed 38,154 participants. Higher WWI is associated with higher depression scores (β = 0.41; 95% CI, 0.36-0.47). After adjusting for various confounding factors, the positive correlation between WWI and depression remained significant (P for trend < 0.0001). Nonlinear positive correlation was detected with a breakpoint of 11.14. ROC analysis shows that compared to other obesity indicators (ROCWWI = 0.593; ROCBMI = 0.584; and ROCWC = 0.581), the correlation between WWI and depression has better discrimination and accuracy. DII mediated 4.93%, SII mediated 5.08%, and sedentary mediated 0.35% of the total association between WWI and depression.
WWI levels were related to an increased likelihood of depression and showed a stronger relationship than BMI and waist circumference. Our findings indicated that WWI may serve as a simple anthropometric index to evaluate depression.
抑郁症已成为一个多层面的全球健康问题，与肥胖有着复杂的联系。体重调整腰围指数（WWI）能够有效评估中心性肥胖，但WWI与抑郁症之间的关系尚未得到充分研究。本研究旨在调查这两个健康参数之间的潜在相关性。
根据美国国家健康与营养检查调查的数据，这项横断面研究采用多元回归分析、亚组分析和平滑曲线拟合来探究WWI与抑郁症之间的关系。使用受试者工作特征（ROC）曲线评估WWI的评估能力，并与其他肥胖指标进行比较。
本研究分析了38154名参与者。较高的WWI与较高的抑郁评分相关（β = 0.41；95%CI，0.36 - 0.47）。在调整各种混杂因素后，WWI与抑郁症之间的正相关仍然显著（趋势P < 0.0001）。检测到非线性正相关，断点为11.14。ROC分析表明，与其他肥胖指标相比（ROCWWI = 0.593；ROCBMI = 0.584；ROCWC = 0.581），WWI与抑郁症之间的相关性具有更好的辨别力和准确性。饮食炎症指数（DII）介导了WWI与抑郁症之间总关联的4.93%，系统性免疫炎症指数（SII）介导了5.08%，久坐介导了0.35%。
WWI水平与抑郁症发生可能性增加相关，且与体重指数（BMI）和腰围相比显示出更强的关联。我们的研究结果表明，WWI可能作为一种简单的人体测量指标来评估抑郁症。
