Yang Mingming, Xu Qiong, Huang Linjuan, Zhu Luqian
Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Front Endocrinol (Lausanne). 2025 May 1;16:1544796. doi: 10.3389/fendo.2025.1544796. eCollection 2025.
Klotho is an anti-aging protein, and obesity and inflammation have been identified as having a relationship with Klotho. This study investigated the correlation between weight-adjusted-waist index(WWI), systemic inflammation index(SII) and soluble Klotho (sKlotho) and explored the potential mediating role of SII.
The association between WWI, SII, and sKlotho was investigated using weighted multivariate linear regression, subgroup analysis, and smoothed curve fitting in this cross-sectional study, which was based on NHANES data. The Bootstrap method was used to test for mediation effects. Covariate selection was validated using the variance inflation factor (VIF).
The study involved a total of 9,506 participants. The results showed that WWI (β=-0.03; 95%CI:-0.04,-0.01; <0.0001) was associated with SII (β=-0.00, 95%CI:-0.00,-0.00:<0.001) and Ln-sKlotho.There was a negative correlation between both WWI and SII and sKlotho. Subgroup analysis showed that gender, age, education, marital status, family income, HEI, PA, hypertension, diabetes, CKD, alcohol use, smoking, and SII did not affect the negative correlation between WWI and sKlotho (FDR-corrected >0.1). The mediation analysis showed that SII played a significant mediating effect in the role of WWI on sKlotho, with SII mediating 6.78% of the relationship between WWI and sKlotho.
There is a negative correlation between WWI and sKlotho, and SII may be an important mediator between WWI and sKlotho. Reducing inflammatory conditions in obese populations may increase sKlotho levels, which in turn may delay organismal aging in middle-aged and elderly people.
Klotho是一种抗衰老蛋白，肥胖和炎症已被证实与Klotho存在关联。本研究调查了体重调整腰围指数（WWI）、全身炎症指数（SII）与可溶性Klotho（sKlotho）之间的相关性，并探讨了SII的潜在中介作用。
在这项基于美国国家健康与营养检查调查（NHANES）数据的横断面研究中，采用加权多元线性回归、亚组分析和平滑曲线拟合来研究WWI、SII与sKlotho之间的关联。使用Bootstrap方法检验中介效应。使用方差膨胀因子（VIF）验证协变量选择。
该研究共纳入9506名参与者。结果显示，WWI（β=-0.03；95%置信区间：-0.04，-0.01；<0.0001）与SII（β=-0.00，95%置信区间：-0.00，-0.00：<0.001）和Ln-sKlotho相关。WWI和SII与sKlotho均呈负相关。亚组分析表明，性别、年龄、教育程度、婚姻状况、家庭收入、健康饮食指数（HEI）、身体活动（PA）、高血压、糖尿病、慢性肾脏病（CKD）、饮酒、吸烟和SII均不影响WWI与sKlotho之间的负相关（经FDR校正>0.1）。中介分析表明，SII在WWI对sKlotho的作用中起显著中介作用，SII介导了WWI与sKlotho之间6.78%的关系。
WWI与sKlotho之间存在负相关，SII可能是WWI与sKlotho之间的重要中介。减轻肥胖人群的炎症状态可能会提高sKlotho水平，进而可能延缓中老年人的机体衰老。
