Imaizumi Hiromichi, Takahashi Atsushi, Takahata Yosuke, Anzai Yukio, Kogure Atsuko, Sakuma Chiharu, Abe Naoto, Sugaya Tatsuro, Fujita Masashi, Hayashi Manabu, Abe Kazumichi, Ohira Hiromasa
Department of Gastroenterology, Fukushima Medical University School of Medicine, Japan.
Department of Gastroenterology, Watari Hospital, Japan.
Intern Med. 2024 Dec 15;63(24):3277-3282. doi: 10.2169/internalmedicine.3119-23. Epub 2024 Apr 23.
Objective A short sleep duration is associated with non-alcoholic fatty liver disease (NAFLD). However, the causal relationship between a short sleep duration and the onset of NAFLD remains unknown because of the lack of any longitudinal studies. Therefore, we evaluated the association between sleep duration and the onset of NAFLD. Methods We evaluated health checkup data for 1,862 NAFLD-free Japanese adults aged 33-86 years at baseline and followed those individuals for a median of 41 months. Hepatic steatosis was examined using ultrasonography (US). The Cox proportional hazards model was used to evaluate the association between sleep duration and NAFLD onset. Results Among the 1,862 participants, 483 (25.9%) developed NAFLD. The proportion of women who developed NAFLD was the highest in the group with a sleep duration of <6 hours and lowest in the group with a sleep duration of 7 to <8 hours. The multivariable-adjusted hazard ratio (95% confidence interval) for the onset of NAFLD in women with a sleep duration <6 hours compared with those with a sleep duration of 7 to <8 hours was 1.55 (1.09-2.20; p=0.02). Conclusion In women, a short sleep duration was independently associated with the onset of NAFLD, thus suggesting that an adequate sleep duration can be a promising preventive factor for the onset of NAFLD in women.
目的 短睡眠时间与非酒精性脂肪性肝病（NAFLD）相关。然而，由于缺乏纵向研究，短睡眠时间与NAFLD发病之间的因果关系尚不清楚。因此，我们评估了睡眠时间与NAFLD发病之间的关联。方法 我们评估了1862名33 - 86岁基线时无NAFLD的日本成年人的健康检查数据，并对这些个体进行了为期41个月的随访。使用超声检查（US）检测肝脂肪变性。采用Cox比例风险模型评估睡眠时间与NAFLD发病之间的关联。结果 在1862名参与者中，483人（25.9%）发生了NAFLD。睡眠时间<6小时组中发生NAFLD的女性比例最高，而睡眠时间为7至<8小时组中最低。睡眠时间<6小时的女性与睡眠时间为7至<8小时的女性相比，NAFLD发病的多变量调整风险比（95%置信区间）为1.55（1.09 - 2.20；p = 0.02）。结论 在女性中，短睡眠时间与NAFLD发病独立相关，这表明充足的睡眠时间可能是女性预防NAFLD发病的一个有前景的因素。
