Iwai N, Kaneda H, Tsuto T, Yanagihara J, Takahashi T
Gastroenterol Jpn. 1985 Oct;20(5):425-30. doi: 10.1007/BF02774778.
The effect of gastrin, secretin and prostaglandin F2 alpha on the canine lower esophageal sphincter (LES) after Nissen fundoplication was investigated by esophageal manometry. The gastrin-stimulated LES pressure was significantly higher intraoperatively 2 and 4 weeks after operation than the preoperative stimulation pressure. On the other hand, the prostaglandin F2 alpha-stimulated LES pressure 2 weeks after operation did not differ significantly from the preoperative stimulation value. At 2 weeks after Nissen fundoplication the LES pressure before secretin injection was significantly higher than the preoperative value. However, the LES pressure after secretin injection did not differ significantly from the preoperative stimulation pressure. Therefore, it seems that exogenously administered gastrin, unlike prostaglandin F2 alpha, stimulates the antireflux mechanism after wrapping of the gastric fundus in the Nissen procedure. It was suggested that secretin reacts against the new muscular sphincter substitute created by wrapping of the gastric fundus in the Nissen procedure.
通过食管测压法研究了胃泌素、促胰液素和前列腺素F2α对犬行nissen胃底折叠术后下食管括约肌（LES）的影响。术中及术后2周和4周时，胃泌素刺激引起的LES压力显著高于术前刺激压力。另一方面，术后2周时前列腺素F2α刺激引起的LES压力与术前刺激值相比无显著差异。nissen胃底折叠术后2周时，注射促胰液素前的LES压力显著高于术前值。然而，注射促胰液素后的LES压力与术前刺激压力相比无显著差异。因此，与前列腺素F2α不同，外源性给予胃泌素似乎在nissen手术中胃底包裹后刺激了抗反流机制。提示促胰液素对nissen手术中胃底包裹形成的新的肌肉性括约肌替代物有反应。
