静脉输注合成人胃泌素-I对犬食管下括约肌（LES）压力的影响及其与胃泌素水平的关系。
The effect of intravenous infusion of synthetic human gastrin-I on lower esophageal sphincter (LES) pressure in the dog and its relation to gastrin level.
作者信息
Jennewein H M, Hummelt H, Siewert R, Waldeck F
出版信息
Digestion. 1976;14(4):376-80. doi: 10.1159/000197956.
To demonstrate the relation between gastrin level and lower esophageal sphincter (LES) pressure, experiments with intravenous infusions of synthetic human gastrin-I (SHG-I) were performed in anaesthetized dogs. The results show that infusions with 5 mug-kg-1-h-1 SHG-I have an initially increasing effect on LES pressure but produce unphysiologically high gastrin blood levels. Physiological levels of gastrin were measured only using an infusion dose of 0.5 mug-kg-1-h-1, which was below the threshold for increasing LES pressure.
为了证明胃泌素水平与食管下括约肌（LES）压力之间的关系，在麻醉犬身上进行了静脉输注合成人胃泌素-I（SHG-I）的实验。结果表明，以5微克·千克⁻¹·小时⁻¹的剂量输注SHG-I最初会使LES压力升高，但会导致胃泌素血液水平达到非生理性的高位。仅使用0.5微克·千克⁻¹·小时⁻¹的输注剂量才测得生理性的胃泌素水平，该剂量低于增加LES压力的阈值。
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