The effect of intravenous infusion of synthetic human gastrin-I on lower esophageal sphincter (LES) pressure in the dog and its relation to gastrin level.

To demonstrate the relation between gastrin level and lower esophageal sphincter (LES) pressure, experiments with intravenous infusions of synthetic human gastrin-I (SHG-I) were performed in anaesthetized dogs. The results show that infusions with 5 mug-kg-1-h-1 SHG-I have an initially increasing effect on LES pressure but produce unphysiologically high gastrin blood levels. Physiological levels of gastrin were measured only using an infusion dose of 0.5 mug-kg-1-h-1, which was below the threshold for increasing LES pressure.