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通过间接免疫荧光法测定输精管切除术和附睾切除术后抗精子自身抗体(作者译)

[Determination of auto-antibodies against spermatozoa after vasectomy and epididymectomy by indirect immunofluorescence (author's transl)].

作者信息

Rost A, Kneppenberg U, Fiedler U

出版信息

Urol Int. 1979;34(5):374-86. doi: 10.1159/000280284.

Abstract

As a result of successful recanalization of the vas deferens, a low pregnancy rate has been observed. The formation of auto-antibodies is considered as cause. In vasectomized and epididymectomized rats, the presence of auto-antibodies against spermatozoa was proven by indirect immunofluorescence. After uni- and/or bilateral obstruction of the vasa, the formation of antibodies against spermatozoa takes place which - after 2 months - proves to be permanent for 9 months, then showing a decreased titre. An animal model is presented suitable for the study of immunological processes in unilateral gonadal diseases.

摘要

由于输精管再通成功,观察到受孕率较低。自身抗体的形成被认为是原因。在输精管切除和附睾切除的大鼠中,通过间接免疫荧光法证实了存在针对精子的自身抗体。在输精管单侧和/或双侧阻塞后,会形成针对精子的抗体,两个月后,这种抗体在9个月内持续存在,之后滴度降低。本文提出了一种适用于研究单侧性腺疾病免疫过程的动物模型。

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