Nishimura T, Tabuki K, Takashima T, Takagi M
Jpn J Antibiot. 1985 Oct;38(10):2925-31.
A bacteriological and clinical study of ceftizoxime suppositories (CZX-S) let to the following results. The CZX serum concentration 10 minutes after insertion of one 250 mg suppository (i.e. 5.7-15.2 mg CZX per kg body weight) ranged from 1.64 to 6.53 micrograms/ml (average: 4.41 micrograms/ml). In one child the concentration 7 minutes after insertion was 4.13 micrograms/ml. Therapeutic responsiveness was recorded as "effective" in 8 (88.9%) of the 9 children who were broken down into 6 with tonsillitis, 1 with pharyngitis, and 2 with UTI. Bacteriological studies conducted in 5 children have confirmed eradication in 4 children, one of whom showing appearance of another strain. The rate of discharge of the suppository within 10 minutes after insertion was 20.4%. Reddening and erosion of the anus were observed in 1 child.
头孢唑肟栓（CZX-S）的细菌学及临床研究得出以下结果。插入一粒250毫克栓剂（即每千克体重5.7 - 15.2毫克头孢唑肟）10分钟后的头孢唑肟血清浓度范围为1.64至6.53微克/毫升（平均：4.41微克/毫升）。一名儿童在插入后7分钟时的浓度为4.13微克/毫升。在9名儿童中，治疗反应记录为“有效”的有8名（88.9%），其中6名患有扁桃体炎，1名患有咽炎，2名患有泌尿道感染。对5名儿童进行的细菌学研究证实，4名儿童的细菌被根除，其中1名出现了另一种菌株。插入后10分钟内栓剂的排出率为20.4%。在1名儿童中观察到肛门发红和糜烂。
