Furukawa S, Okada T
Jpn J Antibiot. 1985 Oct;38(10):2943-51.
A clinical trial of ceftizoxime suppositories (CZX-S) was conducted in children whose chemotherapy was considered to be best performed in this dosage form at the physician's discretion. The subjects were 5 children with infection, consisting of 2 with pneumonia, 1 with tonsillitis, and 2 with UTI. The results were as follows. The clinical response to CZX-S was "markedly effective" in 3 and "effective" in 2, with the 100% effectiveness rate. Neither adverse drug reactions nor abnormal laboratory tests were detected. No unwanted expulsion of the suppository occurred. The serum concentration of CZX 30 minutes after the first insertion ranged from 8.38 to 11.4 micrograms/ml, and the urinary concentration of CZX in the 6-hour urine collections, from 23.6 to 290 micrograms/ml.
在医生认为以这种剂型进行化疗最为适宜的儿童中开展了头孢唑肟栓剂（CZX-S）的临床试验。研究对象为5名感染患儿，其中2名患有肺炎，1名患有扁桃体炎，2名患有泌尿道感染。结果如下。CZX-S的临床反应为3例“显著有效”，2例“有效”，有效率达100%。未检测到药物不良反应及实验室检查异常。未出现栓剂意外排出的情况。首次给药后30分钟时CZX的血清浓度为8.38至11.4微克/毫升，6小时尿液收集时CZX的尿液浓度为23.6至290微克/毫升。
