Sato Y, Iwata S, Akita H, Murai T, Ihara M, Oikawa T, Osano M
Jpn J Antibiot. 1985 Oct;38(10):2877-88.
The fundamental and clinical studies of ceftizoxime suppository (CZX-S) in the field of pediatrics were made, with the following results. The serum concentration of CZX in the CZX-S 250 mg-administered group peaked 6.00-22.5 micrograms/ml during the period of 15 minutes to 1-hour after dosing, and gradually declined thereafter. The half-life was 1.37-3.81 hours. In the CZX-S 125 mg-administered group, the serum concentration peaked 2.25-21.0 micrograms/ml at 15-30 minutes after dosing and decreased with time. The half-life was 0.95--1.84 hours. The 6-hour urinary recovery rate of CZX in the CZX-S 250 mg group was 22.0-47.5%. The 6-hour urinary recovery rate in the CZX-S 125 mg group was 17.2-25.3%. CZX-S was given 12-73 mg/kg/day (divided into 1-3 times) to 7 children with respiratory tract infection etc. who were considered to respond well to the drug. The clinical effectiveness rate was 100% inclusive of "excellent" and "good". The side effect of pain on insertion was encountered in 1 child.
对头孢唑肟栓（CZX-S）进行了儿科领域的基础和临床研究，结果如下。给予250mg CZX-S的组中，给药后15分钟至1小时内，CZX血清浓度峰值为6.00 - 22.5微克/毫升，此后逐渐下降。半衰期为1.37 - 3.81小时。给予125mg CZX-S的组中，给药后15 - 30分钟血清浓度峰值为2.25 - 21.0微克/毫升，并随时间下降。半衰期为0.95 - 1.84小时。250mg CZX-S组中CZX的6小时尿回收率为22.0 - 47.5%。125mg CZX-S组中6小时尿回收率为17.2 - 25.3%。对7名被认为对该药物反应良好的呼吸道感染等患儿给予CZX-S 12 - 73mg/kg/天（分1 - 3次给药）。临床有效率（包括“优”和“良”）为100%。1名患儿出现了插入时疼痛的副作用。
