Motohiro T, Kawakami A, Tanaka K, Koga T, Shimada Y, Tomita N, Sakata Y, Nishiyama T, Tominaga K, Yamashita F
Jpn J Antibiot. 1985 Oct;38(10):2977-3012.
The peak levels of serum ceftizoxime (CZX) after a single rectal administration of CZX-S at doses of 125 and 250 mg in 157 pediatric patients were occurred at 21 approximately 25 minutes in pediatric patients aged less than 1 year and over than 7 years, at 16-20 minutes in 1-3 years patients, at more than 26 minutes in 4-6 years patients. They were 9.45, 9.58, 11.71, 12.43 mcg/ml, respectively. The mean highest levels of serum CZX were 8.56, 10.66, 12.50 mcg/ml after the administration of CZX-S as less than 10.0, 10.1-15.0, 15.1-20.0 mg/kg dose respectively, all of which were occurred at 21-25 25 minutes. A close dose response was observed. The pain of insertion was not observed in any cases. The discharge of melted suppository or defecation after administration was observed in 15.2% of total 184 cases, which was noticed more frequently in the lower aged children. There was no influence by dose. Clinical effects of CZX-S were studied in 72 pediatric patients with various infections. CZX-S was administered rectally at the mean daily dose of 41.0 mg/kg divided into 3 or 4 times for 6 days. Clinical responses were excellent in 46 cases, good in 24 cases, fair in 2 cases. The efficacy rate was 97.2%. Regarding side effects, the pain of insertion was noted in 2 cases (2.8%), diarrhea in 6 cases (8.3%), the elevation of eosinophil in 1 case (1.7%). Bacteriologically, 23 strains (92.0%) out of 25 strains isolated from the patients were eradicated.
在157例儿科患者中，单次直肠给予剂量为125和250mg的头孢唑肟（CZX）-S后，血清头孢唑肟（CZX）的峰值水平在年龄小于1岁和大于7岁的儿科患者中约在21至25分钟出现，1 - 3岁患者在16 - 20分钟出现，4 - 6岁患者在超过26分钟出现。它们分别为9.45、9.58、11.71、12.43 mcg/ml。给予CZX - S剂量分别小于10.0、10.1 - 15.0、15.1 - 20.0mg/kg后，血清CZX的平均最高水平分别为8.56、10.66、12.50 mcg/ml，所有这些均在21 - 25分钟出现。观察到明显的剂量反应关系。在任何情况下均未观察到插入时的疼痛。在总共184例病例中，15.2%观察到给药后融化的栓剂排出或排便，在年龄较小的儿童中更频繁出现。与剂量无关。在72例患有各种感染的儿科患者中研究了CZX - S的临床效果。CZX - S以平均每日剂量41.0mg/kg直肠给药，分3或4次，共6天。临床反应优秀的有46例，良好的有24例，尚可的有2例。有效率为97.2%。关于副作用，2例（2.8%）出现插入时的疼痛，6例（8.3%）出现腹泻，1例（1.7%）出现嗜酸性粒细胞升高。从患者中分离出的25株菌株中，有23株（92.0%）被根除。
