Kinoshita H, Baba S, Mori Y, Suzuki K, Shimada J, Maruo T, Ito H
Jpn J Antibiot. 1985 Oct;38(10):3070-6.
The newly developed ceftizoxime rectal suppository (CZX-S) contains 125 mg or 250 mg ceftizoxime (CZX) in potency. From the laboratory and clinical studies on CZX-S, the following results were obtained. Concentration of CZX in serum and palatine tonsil when 250 mg of CZX-S was rectally administered reached the peak level rapidly. The serum levels were 9.39 micrograms/ml in 30 minutes, 6.00 micrograms/ml in 45 minutes, 4.55 micrograms/ml in 60 minutes, 3.87 micrograms/ml in 90 minutes and 2.65 micrograms/ml in 120 minutes. The palatine tonsil levels were 2.73 micrograms/g in 30 minutes, 1.83 micrograms/g in 45 minutes, 1.54 micrograms/g in 60 minutes, 0.99 micrograms/g in 90 minutes and 0.74 micrograms/g in 120 minutes. About 30% of serum concentrations were distributed into palatine tonsil. CZX-S was administered at a daily dose of 375 mg or 750 mg divided 3 times for 4 approximately 9 days in 19 cases of acute suppurative otitis media of children. The overall clinical effect was excellent in 7 cases, good in 7 cases, fair in 2 cases and poor in 3 cases. The effectiveness rate was 73.7%. No side effects were observed in any cases.
新研制的头孢唑肟直肠栓剂（CZX-S）每粒含头孢唑肟（CZX）125毫克或250毫克有效成分。通过对CZX-S的实验室和临床研究，获得了以下结果。直肠给药250毫克CZX-S后，血清和腭扁桃体中CZX的浓度迅速达到峰值水平。血清浓度在30分钟时为9.39微克/毫升，45分钟时为6.00微克/毫升，60分钟时为4.55微克/毫升，90分钟时为3.87微克/毫升，120分钟时为2.65微克/毫升。腭扁桃体中的浓度在30分钟时为2.73微克/克，45分钟时为1.83微克/克，60分钟时为1.54微克/克，90分钟时为0.99微克/克，120分钟时为0.74微克/克。约30%的血清浓度分布到腭扁桃体中。19例儿童急性化脓性中耳炎患者，CZX-S的日剂量为375毫克或750毫克，分3次给药，共约9天。总体临床效果为优7例，良7例，中2例，差3例。有效率为73.7%。所有病例均未观察到副作用。
