Musa Jonah, Mohammed Caleb, Ocheke Amaka, Kahansim Makswhar, Pam Victor, Daru Patrick
University of Jos Faculty of Medical Sciences.
Kaduna State University Faculty of Medicine, Obstetrics and Gynaecology.
Afr Health Sci. 2018 Sep;18(3):584-595. doi: 10.4314/ahs.v18i3.16.
We sought to estimate the incidence and risk factors associated with development of pre-eclampsia (PET) in Jos, Nigeria.
An open cohort study of singleton pregnant women attending the antenatal clinic of Jos University Teaching Hospital (JUTH), Nigeria between November 2010 and August 2011. Eligible healthy women at ≤ 20 weeks gestation were enrolled and followed up until delivery or development of pre-eclampsia. Baseline demographic characteristics including weight, height and body mass index (BMI) were collected at enrollment. Incidence, risk factors and hazard ratios for developing PET were estimated with corresponding 95% confidence intervals and p-values. All statistical analyses were done with STATA version 11, college station, Texas, USA.
A total of 2416 pregnant women were screened for eligibility out of which 323 were eligible for inclusion. The incidence of PET was 87.9 per 1,000 pregnancies (8.8%). The significant risk factors for PET were previous history of PET (RR=5.1, 95% CI: 2.2-12.1) and BMI at booking ≥ 25 kg/m2 (RR=3.9, 95% CI: 1.5-10.0).
The incidence of PET was relatively high in our cohort in Jos, Nigeria and a previous history of the disease and overweight or obese pregnant women have a significant hazard of developing the disease in the course of gestational follow up. Targeting women with these characteristics for early preventive intervention and close surveillance at the antenatal booking clinic may help in prevention of the disease and its complications.
我们试图估算尼日利亚乔斯地区先兆子痫（PET）的发病率及相关风险因素。
对2010年11月至2011年8月期间在尼日利亚乔斯大学教学医院（JUTH）产前诊所就诊的单胎孕妇进行一项开放性队列研究。纳入妊娠≤20周的符合条件的健康女性，并随访至分娩或出现先兆子痫。在入组时收集包括体重、身高和体重指数（BMI）在内的基线人口统计学特征。估算发生PET的发病率、风险因素及风险比，并给出相应的95%置信区间和p值。所有统计分析均使用美国得克萨斯州大学站市的STATA 11版本完成。
共筛查了2416名孕妇的 eligibility，其中323名符合纳入条件。PET的发病率为每1000例妊娠87.9例（8.8%）。PET的显著风险因素为既往PET病史（RR=5.1，95%CI：2.2 - 12.1）以及孕早期BMI≥25 kg/m2（RR=3.9，95%CI：1.5 - 10.0）。
在我们位于尼日利亚乔斯的队列中，PET的发病率相对较高，既往有该疾病史以及超重或肥胖的孕妇在孕期随访过程中发生该疾病的风险显著。在产前登记诊所针对具有这些特征的女性进行早期预防性干预和密切监测，可能有助于预防该疾病及其并发症。
