Kumar Prashant, Vats Jyoti, Kaur Kiranpreet, Sharma Jyoti, Johar Sanjay
Department of Anaesthesiology and Critical Care, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India.
Department of Anaesthesiology, AIIMS Bhatinda, Punjab, India.
J Anaesthesiol Clin Pharmacol. 2024 Jan-Mar;40(1):69-74. doi: 10.4103/joacp.joacp_253_22. Epub 2024 Mar 14.
The present study was conducted to determine the optimal dose of cisatracurium for intubating conditions and onset and offset of neuromuscular blockade. Data in Indian population are scarce, and hence, the present study was planned to evaluate different doses of cisatracurium.
The prospective randomized double-blind study was conducted on 180 patients of either sex in the age group of 20-60 yrs., having physical status class I to III, scheduled for surgery under general anesthesia. After exclusion 154 patients were randomly divided into three groups comprising 52, 51, and 51, respectively, in Group A, Group B, and group C. They received 0.1 mgkg, 0.2 mgkg, and 0.3 mgkg of cisatracurium, respectively, to facilitate endotracheal intubation. Time of onset, intubating conditions, hemodynamic parameters, signs of histamine release, and recovery time were noted.
Mean time to onset was maximum in group A (4.37 ± 0.48 minutes) and minimum in group C (2.33 ± 0.43 minutes). Intubating conditions were found excellent in 88% patients in group. Change in HR was found to be non-significant at all time periods, but decrease in MAP was found between 2 and 10 minutes in group C. Duration of action was longest in group C.
We conclude that cisatracurium in dose of 0.2 mgkg and 0.3 mgkg provides good-to-excellent intubating conditions within less than 3 minutes.
本研究旨在确定顺式阿曲库铵用于气管插管条件以及神经肌肉阻滞起效和消退的最佳剂量。印度人群的数据较少，因此，本研究计划评估不同剂量的顺式阿曲库铵。
本前瞻性随机双盲研究针对180例年龄在20 - 60岁、身体状况为I至III级、计划在全身麻醉下进行手术的患者，男女不限。排除后，154例患者被随机分为三组，A组、B组和C组分别有52例、51例和51例。他们分别接受0.1mg/kg、0.2mg/kg和0.3mg/kg的顺式阿曲库铵以利于气管插管。记录起效时间、插管条件、血流动力学参数、组胺释放体征和恢复时间。
A组的平均起效时间最长（4.37±0.48分钟），C组最短（2.33±0.43分钟）。C组88%的患者插管条件良好。在所有时间段，心率变化均无显著差异，但C组在2至10分钟时平均动脉压下降。C组的作用持续时间最长。
我们得出结论，0.2mg/kg和0.3mg/kg剂量的顺式阿曲库铵可在不到3分钟内提供良好至优秀的插管条件。
