Salama Maha S, Ashour Mohey A, Taher Ehab S, El-Kon Ismail, Sayed Samy, Alkeridis Lamya Ahmed, Stefan Batrina, Ana-Maria Imbrea, Al-Shuraym Laila A, Shukry Mustafa
Department of Diagnostic and Sonography, Animal Reproduction Research Institute (ARRI), Agricultural Research Center (ARC), Giza, Egypt.
Animal Production Research Institute (APRI), Agricultural Research Center (ARC), Dokki, Egypt.
Vet Anim Sci. 2024 Apr 12;24:100351. doi: 10.1016/j.vas.2024.100351. eCollection 2024 Jun.
Estrus synchronization is important for improving sheep reproduction. To enhance sheep reproduction efficiency, this study investigated the impact of different durations (7 vs. 14 days) and fluorogestone acetate (FGA) doses in intravaginal sponges on estrus synchronization and early pregnancy detection in Ossimi sheep. Two hundred ewes were evenly divided into two groups, each receiving a full 40 mg or a halved 20 mg FGA sponge for their respective durations. The study aimed to optimize breeding efficiency by examining the effectiveness of these treatments in synchronizing estrous cycles and by evaluating the use of serum levels of pregnancy-associated glycoprotein 1 (PAG1) and progesterone (P) as markers for early pregnancy identification. Prostaglandin F and equine chorionic gonadotropin were administered to enhance the synchronization process. Results highlighted that the 7-day treatment protocol significantly improved estrus, pregnancy, and lambing rates compared to the 14-day protocol. Furthermore, pregnant ewes demonstrated elevated levels of PAG1 and P, with PAG1 levels particularly higher in ewes with multiple pregnancies. The findings underscore that the shorter duration of FGA treatment is more effective for reproductive management in Ossimi sheep without significantly affecting PAG1 levels based on the dose or duration of FGA. PAG1 also proved to be a reliable marker for early pregnancy detection, offering a promising approach to identifying fetal numbers early in pregnancy. This research suggests optimizing FGA sponge use could be cost-efficient for improving reproductive efficiency and early pregnancy management in sheep.
发情同步对于提高绵羊繁殖力很重要。为提高绵羊繁殖效率，本研究调查了阴道海绵栓中不同持续时间（7天与14天）和醋酸氟孕酮（FGA）剂量对奥西米绵羊发情同步和早期妊娠检测的影响。200只母羊平均分为两组，每组在各自的持续时间内分别接受完整的40毫克或减半的20毫克FGA海绵栓。该研究旨在通过检查这些处理在同步发情周期方面的有效性，以及通过评估使用妊娠相关糖蛋白1（PAG1）和孕酮（P）的血清水平作为早期妊娠识别标志物，来优化繁殖效率。给予前列腺素F和马绒毛膜促性腺激素以加强同步过程。结果表明，与14天的方案相比，7天的处理方案显著提高了发情、妊娠和产羔率。此外，怀孕母羊的PAG1和P水平升高，多胎母羊的PAG1水平尤其更高。研究结果强调，较短持续时间的FGA处理对奥西米绵羊的繁殖管理更有效，且基于FGA的剂量或持续时间不会显著影响PAG1水平。PAG1也被证明是早期妊娠检测的可靠标志物，为在妊娠早期识别胎儿数量提供了一种有前景的方法。这项研究表明，优化FGA海绵栓的使用对于提高绵羊的繁殖效率和早期妊娠管理可能具有成本效益。
