Ferguson M M, McDonald F G, Alexander W D
Immunol Lett. 1985;11(2):117-20. doi: 10.1016/0165-2478(85)90153-1.
The thiocarbamide antithyroid drugs, methimazole and propylthiouracil, suppressed natural killer (NK) cell-induced cytolysis in vitro (determined by the release of 51Cr-chromate from labelled target cells) in a dose-dependent manner. Parallel experiments demonstrated a similar reduction in NK cell luminol chemiluminescence during activation by K562 tumour cells. It would appear, therefore, that an association may exist between NK cell-induced cytolysis and the peroxidase/oxygenase activity of these lymphocytes.
硫脲类抗甲状腺药物，甲巯咪唑和丙硫氧嘧啶，在体外以剂量依赖的方式抑制自然杀伤（NK）细胞诱导的细胞溶解（通过标记靶细胞释放51Cr铬酸盐来测定）。平行实验表明，在被K562肿瘤细胞激活期间，NK细胞鲁米诺化学发光也有类似程度的降低。因此，似乎NK细胞诱导的细胞溶解与这些淋巴细胞的过氧化物酶/加氧酶活性之间可能存在关联。
