Ferguson M M, McDonald F G
FEBS Lett. 1985 Oct 21;191(1):145-8. doi: 10.1016/0014-5793(85)81011-5.
Natural killer (NK) cells are large granular lymphocytes attributed with the ability to lyse certain tumour cells. Previous studies on NK cells have demonstrated only an in vivo suppression of NK cell activity by 17 beta-oestradiol. The suppressive action of oestrogen on other peroxidase-containing leukocytes by virtue of its redox potential has already been documented. In the present study oestrogen suppressed NK cell cytolysis in vitro (determined by the release of [51Cr]chromate from radiolabelled cells) in a dose-dependent manner (p less than 0.01). Parallel experiments demonstrated a similar reduction in NK cell luminol chemiluminescence during activation by K562 tumour cells. Therefore, it would appear that there may be an association between NK cell lysis and their peroxidase/oxygenase activity.
自然杀伤（NK）细胞是一种大颗粒淋巴细胞，具有裂解某些肿瘤细胞的能力。先前关于NK细胞的研究仅表明17β-雌二醇在体内对NK细胞活性有抑制作用。雌激素凭借其氧化还原电位对其他含过氧化物酶的白细胞的抑制作用已有文献记载。在本研究中，雌激素在体外以剂量依赖的方式抑制NK细胞的细胞溶解作用（通过放射性标记细胞释放[51Cr]铬酸盐来测定）（p<0.01）。平行实验表明，在被K562肿瘤细胞激活期间，NK细胞鲁米诺化学发光也有类似程度的降低。因此，似乎NK细胞的裂解与其过氧化物酶/加氧酶活性之间可能存在关联。
