低结核病流行地区非结核分枝杆菌肺病的趋势及治疗结果：一项回顾性分析
Trends in Non-Tuberculous Mycobacterial Lung Disease and Treatment Outcomes in a Low-Tuberculosis Prevalence Setting: A Retrospective Analysis.
作者信息
Mohanty Biplob Kumar, Eagan Tomas Mikal Lind, Aarli Bernt Bøgvald, Skutlaberg Dag Harald, Mustafa Tehmina
机构信息
Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway.
Department of Thoracic Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
出版信息
Pathogens. 2024 Apr 22;13(4):344. doi: 10.3390/pathogens13040344.
BACKGROUND
Information on the management of non-tuberculous mycobacterial (NTM) lung infection and disease is scarce. The aim of this study was to investigate the trends in NTM lung infections, and the factors associated with the initiation of treatment and treatment outcomes.
METHODS
A retrospective analysis was carried out on patient medical records from Haukeland University Hospital, Bergen, Norway, from 2000 to 2021.
RESULTS
Among 154 patients with NTM lung infection, the majority (70%) were older than 65 years, and 49% had an underlying pulmonary comorbidity. The most frequently observed mycobacterial species was complex (MAC), followed by and . In total, 72 (47%) patients received antibiotic treatment. Patients with high symptom scores, aged below 65, and with MAC infection had more than three times the odds of receiving antibiotic treatment. A favourable response and culture conversion was observed in 53 of 72 (74%) patients. However, 17 (32%) of them had a relapse. Out of 82 patients who did not receive treatment, 45 (55%) had spontaneous culture conversion, and 8 (18%) of them had a relapse. No factor was identified to be significantly associated with a favourable treatment response.
CONCLUSION
A favourable response to treatment was seen in 74% of patients with a high relapse rate.
背景
关于非结核分枝杆菌（NTM）肺部感染和疾病管理的信息匮乏。本研究的目的是调查NTM肺部感染的趋势，以及与治疗起始和治疗结果相关的因素。
方法
对挪威卑尔根豪克兰大学医院2000年至2021年的患者病历进行回顾性分析。
结果
在154例NTM肺部感染患者中，大多数（70%）年龄超过65岁，49%有潜在肺部合并症。最常观察到的分枝杆菌种类是鸟分枝杆菌复合群（MAC），其次是堪萨斯分枝杆菌和脓肿分枝杆菌。共有72例（47%）患者接受了抗生素治疗。症状评分高、年龄低于65岁且感染MAC的患者接受抗生素治疗的几率是其他患者的三倍多。72例患者中有53例（74%）观察到良好反应和培养转阴。然而，其中17例（32%）复发。在82例未接受治疗的患者中，45例（55%）培养结果自发转阴，其中8例（18%）复发。未发现有因素与良好的治疗反应显著相关。
结论
74%接受治疗的患者反应良好，但复发率高。
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