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肾功能快速变化对人体血浆降钙素和甲状旁腺激素的影响。

Effect of rapid variation of renal function on plasma calcitonin and parathyroid hormone in man.

作者信息

Fuss M, Bergans A, Geurts J, Brauman H, Corvilain J

出版信息

Acta Endocrinol (Copenh). 1979 Sep;92(1):130-7. doi: 10.1530/acta.0.0920130.

DOI:10.1530/acta.0.0920130
PMID:386684
Abstract

Plasma levels of immunoreactive calcitonin (iCT) and parathyroid hormone (iPTH) have been measured sequentially in 6 patients following successful renal transplantation (RT) and in 3 patients during the recovery phase of acute renal failure (ARF). iCT and iPTH returned to normal values within a few days when glomerular filtration improved; both hormones rose in cases of acute graft rejection. Unlike iPTH iCT did not follow closely the variations of creatinine, iCT even rising before creatinine in one graft rejection. These observations could possibly be explained by a dissociation between the renal metabolism of iCT and the glomerular filtration.

摘要

对6例肾移植成功后的患者以及3例急性肾衰竭(ARF)恢复期的患者,连续检测了血浆免疫反应性降钙素(iCT)和甲状旁腺激素(iPTH)的水平。当肾小球滤过功能改善时,iCT和iPTH在数天内恢复至正常水平;在急性移植排斥的情况下,这两种激素水平均升高。与iPTH不同,iCT并不紧密跟随肌酐的变化,在一次移植排斥中,iCT甚至在肌酐升高之前就升高了。这些观察结果可能是由于iCT的肾脏代谢与肾小球滤过之间的分离所致。

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