儿童脑脊液中的免疫反应性甲状旁腺激素和降钙素。

Immunoreactive parathyroid hormone and calcitonin in children's cerebrospinal fluid.

作者信息

Saggese G, Bertelloni S, Baroncelli G I, Abadessa A, Macchia P, Bottone U

出版信息

Horm Res. 1986;23(3):177-80. doi: 10.1159/000180319.

Abstract

Cerebrospinal fluid (CSF) levels of immunoreactive parathyroid hormone (iPTH) and immunoreactive calcitonin (iCT) were measured by radioimmunoassay in 23 outpatient leukemic children on maintenance chemotherapy. These hormones were detectable in the CSF of all patients: iPTH 148 +/- 11 pg/ml (mean +/- SEM); iCT 14.3 +/- 0.8 pg/ml. iPTH and iCT were also measured in serum (iPTH 396 +/- 18 pg/ml; iCT 32.3 +/- 1.4 pg/ml). CSF values were significantly lower (p less than 0.001) than serum concentrations; no significant correlation between the two compartments was found. Our study indicates the presence of iPTH and iCT in the CSF of children.

摘要

采用放射免疫分析法对23例接受维持化疗的门诊白血病患儿的脑脊液（CSF）中免疫反应性甲状旁腺激素（iPTH）和免疫反应性降钙素（iCT）水平进行了测定。所有患者的脑脊液中均可检测到这些激素：iPTH为148±11 pg/ml（平均值±标准误）；iCT为14.3±0.8 pg/ml。同时也测定了血清中的iPTH和iCT（iPTH为396±18 pg/ml；iCT为32.3±1.4 pg/ml）。脑脊液中的数值显著低于血清浓度（p<0.001）；未发现两个部位之间存在显著相关性。我们的研究表明儿童脑脊液中存在iPTH和iCT。