The Second Clinical Medical School, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Department of Gastroenterology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China.
Medicine (Baltimore). 2024 Apr 26;103(17):e37735. doi: 10.1097/MD.0000000000037735.
Growing evidences of recent studies have shown that gut microbrome are causally related to digestive system diseases (DSDs). However, causal relationships between the gut microbiota and the risk of DSDs still remain unclear. We utilized identified gut microbiota based on class, family, genus, order and phylum information and digestive system diseases genome-wide association study (GWAS) dataset for two-sample Mendelian randomization (MR) analysis. The inverse variance weighted (IVW) method was used to evaluate causal relationships between gut microbiota and 7 DSDs, including chronic gastritis, colorectal cancer, Crohn's disease, gastric cancer, gastric ulcer, irritable bowel syndrome and esophageal cancer. Finally, we verified the robustness of MR results based on heterogeneity and pleiotropy analysis. We discovered 15 causal associations with genetic liabilities in the gut microbiota and DSDs, such as genus Victivallis, genus RuminococcaceaeUCG005, genus Ruminococcusgauvreauiigroup, genus Oxalobacter and so on. Our MR analysis revealed that the gut microbiota is causally associated with DSDs. Further researches of the gut microbiota and the pathogenesis of DSDs are still significant and provide new methods for the prevention and treatment of DSDs.
越来越多的研究证据表明，肠道微生物群与消化系统疾病（DSD）有因果关系。然而，肠道微生物群与 DSD 风险之间的因果关系仍不清楚。我们利用基于分类、科、属、目和门信息的已识别肠道微生物群和消化系统疾病全基因组关联研究（GWAS）数据集进行两样本孟德尔随机化（MR）分析。反向方差加权（IVW）方法用于评估肠道微生物群与 7 种 DSD 之间的因果关系，包括慢性胃炎、结直肠癌、克罗恩病、胃癌、胃溃疡、肠易激综合征和食管癌。最后，我们基于异质性和多效性分析验证了 MR 结果的稳健性。我们发现了 15 种与肠道微生物群和 DSD 遗传易感性相关的因果关联，例如属 Victivallis、属 RuminococcaceaeUCG005、属 Ruminococcusgauvreauiigroup、属 Oxalobacter 等。我们的 MR 分析表明，肠道微生物群与 DSD 有因果关系。进一步研究肠道微生物群与 DSD 的发病机制仍然具有重要意义，并为 DSD 的预防和治疗提供了新的方法。
