Department of Blood Transfusion, Shijiazhuang Fourth Hospital, Shijiazhuang City, Hebei Province, China.
Department of Blood Transfusion, Zhengding County People's Hospital, Shijiazhuang City, Hebei Province, China.
Medicine (Baltimore). 2024 Apr 26;103(17):e37958. doi: 10.1097/MD.0000000000037958.
This study aimed to explore the correlation between vitamin D3 and arginine (Arg) metabolism indicators in newborns with amino acid metabolism disorders. Based on clinical data, 30 newborns with amino acid metabolism diseases admitted to Shijiazhuang Fourth Hospital from June 2021 to June 2022 were selected as the disease group, and 30 healthy newborns from the same period were selected as the healthy group. After enrollment, blood samples were collected to measure the levels of Arg, Glycine (Gly), and vitamin D3 levels. The levels of Arg metabolism indicators and vitamin D3 levels in the 2 groups and the correlation between vitamin D3 levels and Arg metabolism indicators in the affected group were analyzed. The Arg level in the diseased group was higher than that in the healthy group, whereas the Gly and vitamin D3 levels were lower than those in the healthy group (P < .05). There was a significant negative correlation between vitamin D3 and Arg levels in the affected group, and a significant positive correlation with Gly levels (P < .05). Newborns with amino acid metabolism disorders have abnormally high Arg levels, significantly reduced Gly levels, and significantly decreased vitamin D3 levels. The degree of decline was closely related to the levels of indicators of Arg metabolism. Vitamin D3 supplementation can improve the Arg metabolism status of newborns with amino acid metabolism disorders.
本研究旨在探讨氨基酸代谢紊乱新生儿维生素 D3 与精氨酸（Arg）代谢指标的相关性。基于临床数据，选取 2021 年 6 月至 2022 年 6 月在石家庄市第四医院收治的 30 例氨基酸代谢疾病新生儿为疾病组，同期选取 30 例健康新生儿为健康组。入组后采集血样，测定 Arg、甘氨酸（Gly）和维生素 D3 水平。分析 2 组 Arg 代谢指标及维生素 D3 水平，以及疾病组中维生素 D3 水平与 Arg 代谢指标的相关性。疾病组 Arg 水平高于健康组，Gly 和维生素 D3 水平低于健康组（P ＜.05）。疾病组维生素 D3 与 Arg 水平呈显著负相关，与 Gly 水平呈显著正相关（P ＜.05）。氨基酸代谢障碍新生儿 Arg 水平异常升高，Gly 水平显著降低，维生素 D3 水平显著降低，下降程度与 Arg 代谢指标水平密切相关。补充维生素 D3 可改善氨基酸代谢障碍新生儿的 Arg 代谢状态。
