Department of Embryology, School of Basic Medical Sciences, Shanxi Medical University, Shanxi, China.
Animal Experiment Center, Shanxi Medical University, Shanxi, China.
Medicine (Baltimore). 2024 Apr 26;103(17):e37611. doi: 10.1097/MD.0000000000037611.
Osteoarthritis is a common degenerative joint disease that is highly prevalent in the elderly population. Along with the occurrence of sports injuries, osteoarthritis is gradually showing a younger trend. Osteoarthritis has many causative factors, and its pathogenesis is currently unknown. Cellular senescence is a stable form of cell cycle arrest exhibited by cells in response to external stimuli and plays a role in a variety of diseases. And it is only in the last decade or so that cellular senescence has gradually become cross-linked with osteoarthritis. However, there is no comprehensive bibliometric analysis in this field. The aim of this study is to present the current status and research hotspots of cellular senescence in the field of osteoarthritis, and to predict the future trends of cellular senescence in osteoarthritis research from a bibliometric perspective.
This study included 298 records of cellular senescence associated with osteoarthritis from 2009 to 2023, with data from the Web of Science Core Collection database. CiteSpace, Scimago Graphica software, VOSviewer, and the R package "bibliometrix" software were used to analyze regions, institutions, journals, authors, and keywords to predict recent trends in cellular senescence related to osteoarthritis research.
The number of publications related to cellular senescence associated with osteoarthritis is increasing year by year. China and the United States contribute more than 70% of the publications and are the mainstay of research in this field. Central South University is the most active institution with the largest number of publications. International Journal of Molecular Sciences is the most popular journal in the field with the largest number of publications, while Osteoarthritis and Cartilage is the most cited journal. Loeser, Richard F. is not only the most prolific author, but also the most frequently cited author, contributing greatly to the field.
In the last decade or so, this is the first bibliometric study that systematically describes the current status and development trend of research on cellular senescence associated with osteoarthritis. The study comprehensively and systematically summarizes and concludes the research hotspots and development trends, providing valuable references for researchers in this field.
骨关节炎是一种常见的退行性关节疾病，在老年人群中发病率很高。随着运动损伤的发生，骨关节炎逐渐呈现年轻化趋势。骨关节炎有许多致病因素，其发病机制尚不清楚。细胞衰老是细胞对外界刺激产生的一种稳定的细胞周期停滞形式，在多种疾病中发挥作用。只是在过去的十年左右，细胞衰老才逐渐与骨关节炎联系起来。然而，在这个领域还没有全面的文献计量分析。本研究旨在呈现细胞衰老与骨关节炎领域的现状和研究热点，并从文献计量学的角度预测细胞衰老在骨关节炎研究中的未来趋势。
本研究纳入了 2009 年至 2023 年与骨关节炎相关的细胞衰老的 298 条记录，数据来自 Web of Science 核心合集数据库。使用 CiteSpace、Scimago Graphica 软件、VOSviewer 和 R 包“bibliometrix”软件对地区、机构、期刊、作者和关键词进行分析，以预测与细胞衰老相关的骨关节炎研究的近期趋势。
与细胞衰老相关的骨关节炎的出版物数量逐年增加。中国和美国的出版物占比超过 70%，是该领域的主要研究力量。中南大学是最活跃的机构，发表的论文数量最多。国际分子科学杂志是该领域发表论文最多的期刊，而骨关节炎与软骨则是被引最多的期刊。Loeser，Richard F.不仅是最多产的作者，也是被引最多的作者，对该领域做出了巨大贡献。
在过去的十年左右，这是第一项系统描述与骨关节炎相关的细胞衰老研究现状和发展趋势的文献计量研究。该研究全面系统地总结和总结了研究热点和发展趋势，为该领域的研究人员提供了有价值的参考。
