National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, USA.
National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, USA; Behavioral Biology Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Clin Neurophysiol. 2024 Jul;163:22-36. doi: 10.1016/j.clinph.2024.03.036. Epub 2024 Apr 10.
Coupling between the amplitude envelopes (AEs) of regional cortical activity reflects mechanisms that coordinate the excitability of large-scale cortical networks. We used resting-state MEG recordings to investigate the association between alterations in the coupling of cortical AEs and symptoms of post-traumatic stress disorder (PTSD).
Participants (n = 96) were service members with combat exposure and various levels of post-traumatic stress severity (PTSS). We assessed the correlation between PTSS and (1) coupling of broadband cortical AEs of beta band activity, (2) coupling of the low- (<0.5 Hz) and high-frequency (>0.5 Hz) components of the AEs, and (3) their time-varying patterns.
PTSS was associated with widespread hypoconnectivity assessed from the broadband AE fluctuations, which correlated with subscores for the negative thoughts and feelings/emotional numbing (NTF/EN) and hyperarousal clusters of symptoms. Higher NTF/EN scores were also associated with smaller increases in resting-state functional connectivity (rsFC) with time during the recordings. The distinct patterns of rsFC in PTSD were primarily due to differences in the coupling of low-frequency (infraslow) fluctuations of the AEs of beta band activity.
Our findings implicate the mechanisms underlying the regulation/coupling of infraslow oscillations in the alterations of rsFC assessed from broadband AEs and in PTSD symptomatology.
Altered coordination of infraslow amplitude fluctuations across large-scale cortical networks can contribute to network dysfunction and may provide a target for treatment in PTSD.
区域皮质活动的幅度包络（AE）之间的耦合反映了协调大规模皮质网络兴奋性的机制。我们使用静息状态 MEG 记录来研究皮质 AE 耦合的变化与创伤后应激障碍（PTSD）症状之间的关联。
参与者（n=96）为有战斗经历和不同程度创伤后应激严重程度（PTSS）的现役军人。我们评估了 PTSS 与（1）β频段活动的宽带皮质 AE 的耦合，（2）AE 的低频（<0.5 Hz）和高频（>0.5 Hz）分量的耦合，以及（3）它们的时变模式之间的相关性。
PTSS 与广泛的低耦合有关，从宽带 AE 波动中评估，这与负性思维和感觉/情感麻木（NTF/EN）和过度唤醒症状的亚量表相关。较高的 NTF/EN 分数也与记录期间随着时间的推移静息状态功能连接（rsFC）的增加较小相关。PTSD 中的 rsFC 独特模式主要是由于β频段活动的 AE 的低频（亚慢）波动的耦合差异所致。
我们的研究结果表明，在从宽带 AE 评估的 rsFC 和 PTSD 症状的改变中，亚慢振荡的调节/耦合机制。
跨大规模皮质网络的亚慢幅度波动的协调改变可能导致网络功能障碍，并可能为 PTSD 的治疗提供目标。
