Cheshmi Behzad, Jafari Zahra, Naseri Mohammad Ali, Davari Heidar Ali
Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Broujerd Branch, Islamic Azad University, Broujerd, Iran.
Department of Orthodontics and Dentofacial Orthopedics, Broujerd Branch, Islamic Azad University, Broujerd, Iran.
Maxillofac Plast Reconstr Surg. 2020 Aug 8;42(1):26. doi: 10.1186/s40902-020-00270-7. eCollection 2020 Dec.
Orofacial clefts (OFCs) comprise a wide range of malformations, including cleft lip, cleft palate, and cleft lip with cleft palate, which can vary in terms of etiology, severity, and disease burden.
This study aimed to evaluate the correlation between various risk factors and orofacial cleft disorder spectrum in newborns.
A total of 323 cases and 400 controls were enrolled in this study and evaluated in terms of the maternal history of abortion or miscarriage, child's sex, maternal and paternal age, maternal history of systemic disease, history of medication therapy during pregnancy, birth order, consanguineous marriage, and complications during pregnancy.
Analysis of the results suggested that consanguineous marriage, a maternal history of abortion/miscarriage, and complications during pregnancy could potentially increase the risk of OFCs in children ( < 0.05). However, the analyses revealed that the other variables could not potentially increase the risk of OFCs ( > 0.05).
Multiple cofactors may simultaneously contribute to the formation of such abnormalities; therefore, a comprehensive, multidisciplinary care program is necessary to ensure a successful pregnancy period and the birth of a healthy newborn.
口面部裂隙（OFCs）包括多种畸形，如唇裂、腭裂以及唇腭裂，其病因、严重程度和疾病负担各不相同。
本研究旨在评估新生儿各种风险因素与口面部裂隙疾病谱之间的相关性。
本研究共纳入323例病例和400例对照，从母亲流产或 miscarriage 史、孩子性别、父母年龄、母亲全身性疾病史、孕期药物治疗史、出生顺序、近亲结婚以及孕期并发症等方面进行评估。
结果分析表明，近亲结婚、母亲流产/ miscarriage 史以及孕期并发症可能会增加儿童患口面部裂隙的风险（<0.05）。然而，分析显示其他变量不会增加患口面部裂隙的风险（>0.05）。
多种协同因素可能同时导致此类异常的形成；因此，需要一个全面的多学科护理计划，以确保孕期顺利并生出健康的新生儿。
