Li Meng, Tang Shusheng, Peng Xinyan, Sharma Gaurav, Yin Shutao, Hao Zhihui, Li Jichang, Shen Jianzhong, Dai Chongshan
National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
College of Life Sciences, Yantai University, Yantai 264000, China.
Antioxidants (Basel). 2024 Apr 11;13(4):452. doi: 10.3390/antiox13040452.
Aflatoxin (AFT) contamination poses a significant global public health and safety concern, prompting widespread apprehension. Of the various AFTs, aflatoxin B1 (AFB1) stands out for its pronounced toxicity and its association with a spectrum of chronic ailments, including cardiovascular disease, neurodegenerative disorders, and cancer. Lycopene, a lipid-soluble natural carotenoid, has emerged as a potential mitigator of the deleterious effects induced by AFB1 exposure, spanning cardiac injury, hepatotoxicity, nephrotoxicity, intestinal damage, and reproductive impairment. This protective mechanism operates by reducing oxidative stress, inflammation, and lipid peroxidation, and activating the mitochondrial apoptotic pathway, facilitating the activation of mitochondrial biogenesis, the endogenous antioxidant system, and the nuclear factor erythroid 2-related factor 2 (Nrf2)/kelch-like ECH-associated protein 1 (KEAP1) and peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) pathways, as well as regulating the activities of cytochrome P450 (CYP450) enzymes. This review provides an overview of the protective effects of lycopene against AFB1 exposure-induced toxicity and the underlying molecular mechanisms. Furthermore, it explores the safety profile and potential clinical applications of lycopene. The present review underscores lycopene's potential as a promising detoxification agent against AFB1 exposure, with the intent to stimulate further research and practical utilization in this domain.
黄曲霉毒素（AFT）污染是一个重大的全球公共卫生和安全问题，引发了广泛担忧。在各种AFT中，黄曲霉毒素B1（AFB1）因其显著的毒性以及与一系列慢性疾病（包括心血管疾病、神经退行性疾病和癌症）的关联而备受关注。番茄红素是一种脂溶性天然类胡萝卜素，已成为减轻AFB1暴露所致有害影响的潜在物质，这些有害影响包括心脏损伤、肝毒性、肾毒性、肠道损伤和生殖功能损害。这种保护机制通过降低氧化应激、炎症和脂质过氧化作用，激活线粒体凋亡途径，促进线粒体生物发生、内源性抗氧化系统以及核因子红细胞2相关因子2（Nrf2）/ Kelch样ECH相关蛋白1（KEAP1）和过氧化物酶体增殖物激活受体γ共激活因子1（PGC-1）途径的激活，并调节细胞色素P450（CYP450）酶的活性来发挥作用。本综述概述了番茄红素对AFB1暴露诱导的毒性的保护作用及其潜在的分子机制。此外，还探讨了番茄红素的安全性概况和潜在的临床应用。本综述强调了番茄红素作为一种有前景的针对AFB1暴露的解毒剂的潜力，旨在激发该领域的进一步研究和实际应用。
