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腹腔镜子宫肌瘤切除术对妊娠结局的影响:一项系统评价

The Impact of Laparoscopic Myomectomy on Pregnancy Outcomes: A Systematic Review.

作者信息

Balulescu Ligia, Brasoveanu Simona, Pirtea Marilena, Grigoras Dorin, Secoșan Cristina, Olaru Flavius, Erdelean Dragos, Margan Mădălin-Marius, Alexandru Alexandru, Ivan Cristiana-Smaranda, Pirtea Laurențiu

机构信息

Department of Obstetrics and Gynecology, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Department of Functional Sciences, Discipline of Public Health, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.

出版信息

J Pers Med. 2024 Mar 25;14(4):340. doi: 10.3390/jpm14040340.

Abstract

STUDY OBJECTIVE

The objective of this systematic review is to investigate the impact of laparoscopic myomectomy techniques on pregnancy outcomes, with a specific focus on the correlation between the type of suture used during the procedure and the incidence of uterine rupture. Additionally, the study aims to examine how the localization and size of myomas, key factors in laparoscopic myomectomy, may influence fertility outcomes.

DATA SOURCES

extensive searches were conducted using MDPI, PubMed, Web of Science, and Cochrane Library databases from 2008 to November 2023.

METHODS OF STUDY SELECTION

The study involved women of reproductive age diagnosed with fibroids who underwent surgical removal of fibroids using either laparotomy or laparoscopy. The evaluation of pregnancy outcomes focused on indicators such as live birth rates, miscarriage rates, stillbirth rates, premature delivery rates, and cases of uterine rupture. Quality assessment was systematically performed by employing the National Institutes of Health Study Quality Assessment Tools, with the subsequent formulation of clinical recommendations that were meticulously graded in accordance with the robustness of the underlying evidence.

RESULTS

The pregnancy outcomes post-myoma treatment, as reflected in one of the presented tables, show a promising number of pregnancies and live births, but also indicate the potential risks of miscarriages and preterm births. The diversity in outcomes observed among various studies underscores the imperative for tailored patient care, as well as the necessity for additional research aimed at optimizing fertility and pregnancy outcomes following myoma treatment.

CONCLUSION

This study offers insights into the criteria for patient selection and intraoperative methodologies specifically related to laparoscopic myomectomy. To enhance our understanding of the associations between fibroid characteristics (location, size) and reproductive outcomes, additional research is warranted, particularly through well-designed clinical trials.

摘要

研究目的

本系统评价的目的是研究腹腔镜子宫肌瘤剔除术技术对妊娠结局的影响,特别关注手术过程中使用的缝合类型与子宫破裂发生率之间的相关性。此外,该研究旨在探讨子宫肌瘤的位置和大小(腹腔镜子宫肌瘤剔除术的关键因素)如何影响生育结局。

数据来源

2008年至2023年11月期间,使用MDPI、PubMed、科学网和考克兰图书馆数据库进行了广泛检索。

研究选择方法

该研究纳入了被诊断为子宫肌瘤的育龄妇女,她们通过开腹手术或腹腔镜手术切除了肌瘤。妊娠结局评估集中在活产率、流产率、死产率、早产率和子宫破裂病例等指标上。采用美国国立卫生研究院研究质量评估工具系统地进行质量评估,随后根据基础证据的稳健性精心制定临床建议并进行分级。

结果

其中一张表格所反映的肌瘤治疗后的妊娠结局显示,妊娠和活产数量可观,但也表明存在流产和早产的潜在风险。不同研究中观察到的结局差异强调了个性化患者护理的必要性,以及开展更多旨在优化肌瘤治疗后生育和妊娠结局的研究的必要性。

结论

本研究为腹腔镜子宫肌瘤剔除术的患者选择标准和术中方法提供了见解。为了加深我们对肌瘤特征(位置、大小)与生殖结局之间关联的理解,有必要开展更多研究,特别是通过精心设计的临床试验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcb/11051497/7f1f04a87ab9/jpm-14-00340-g001.jpg

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