Oliveira Catarina, Vilela Marta, Nobre Menezes Miguel, Silva Marques João, Jorge Cláudia Moreira, Rodrigues Tiago, Almeida Duarte José, Marques da Costa José, Carrilho Ferreira Pedro, Francisco Ana Rita, Cardoso Pedro Pinto, Pinto Fausto J
Serviço de Cardiologia, Departamento de Coração e Vasos, CHULN Hospital de Santa Maria, Av Prof. Egas Moniz, 1649-028 Lisboa, Portugal.
Structural and Coronary Heart Disease Unit, Centro Cardiovascular da Universidade de Lisboa (CCUL@RISE), Faculdade de Medicina, Universidade de Lisboa, Av Prof. Egas Moniz, 1649-028 Lisboa, Portugal.
J Pers Med. 2024 Apr 22;14(4):438. doi: 10.3390/jpm14040438.
: Coronary artery calcification is a predictor of adverse outcomes after percutaneous coronary intervention (PCI). Intravascular lithotripsy (IVL) is a promising tool for the treatment of calcified lesions. The aim of this study was to assess the effectiveness and safety of IVL. : A single-center observational study of PCI procedure, with assessment of the outcomes of patients undergoing PCI using IVL, was performed. Angiographic procedural success was used as the primary effectiveness endpoint. The primary safety endpoint was defined as a composite of cardiac death, myocardial infarction and target vessel revascularization within 30 days. : A total of 111 patients were included. Indications for PCI spanned the spectrum of chronic (53.2%) and acute coronary syndromes (43%). Lesion preparation before IVL was performed with non-compliant (42%), cutting or OPN (14.4%) balloons and with atherectomy techniques in 11% of procedures. Intravascular imaging was used in 21.6% of procedures. The primary effectiveness endpoint was achieved in 100% and the primary safety endpoint in 3.6% of procedures. Peri-procedural complications were minimal and successfully resolved. : IVL was an effective and safe technique for the treatment of calcified coronary lesions. These findings contribute to the growing body of evidence supporting the use of IVL in the management of these challenging scenarios.
冠状动脉钙化是经皮冠状动脉介入治疗（PCI）后不良结局的预测指标。血管内碎石术（IVL）是治疗钙化病变的一种有前景的工具。本研究的目的是评估IVL的有效性和安全性。：进行了一项关于PCI手术的单中心观察性研究，评估接受IVL的PCI患者的结局。血管造影手术成功被用作主要有效性终点。主要安全终点定义为30天内心脏死亡、心肌梗死和靶血管血运重建的复合终点。：共纳入111例患者。PCI的适应证涵盖慢性（53.2%）和急性冠状动脉综合征（43%）。IVL前的病变预处理采用非顺应性球囊（42%）、切割球囊或定向斑块旋切球囊（14.4%），11%的手术采用旋磨术。21.6%的手术使用了血管内成像。100%的手术达到了主要有效性终点，3.6%的手术达到了主要安全终点。围手术期并发症极少且成功解决。：IVL是治疗冠状动脉钙化病变的一种有效且安全的技术。这些发现为支持在这些具有挑战性的情况下使用IVL的越来越多的证据做出了贡献。
