Kawasaki Akihiro, Matsuzaki Yutaka, Kawada Taku
College of Social Csciences, Ritsumeikan University, Kyoto 603-8577, Japan.
Graduate School of Education, Tohoku University, Sendai 980-8576, Japan.
J Clin Med. 2024 Apr 20;13(8):2399. doi: 10.3390/jcm13082399.
: The primary purpose of this study was to preliminarily examine the effects of autonomic nervous system activity on the dorsolateral prefrontal cortex. Recent studies have examined approaches to modulating autonomic activity using invasive and non-invasive methods, but the effects of changes in autonomic activity during cognitive tasks on the dorsolateral prefrontal cortex have not been fully investigated. The purpose of this preliminary investigation was to examine changes in autonomic activity and blood oxygen saturation in the dorsolateral prefrontal cortex during reading tasks induced by vagus nerve stimulation using a microcone patch. : A cohort of 40 typically developing adults was enrolled in this study. We carefully examined changes in autonomic nervous system activity and blood oxygen saturation in the dorsolateral prefrontal cortex during a reading task in two conditions: with and without microcone patch stimulation. : Significant changes in brain activation in the dorsolateral prefrontal cortext due to microcone patch stimulation were confirmed. In addition, hierarchical multiple regression analysis revealed specific changes in reading task-related blood oxygen saturation in the dorsolateral prefrontal region during microcone patch stimulation. : It should be recognized that this study is a preliminary investigation and does not have immediate clinical applications. However, our results suggest that changes in autonomic nervous system activity induced by external vagal stimulation may affect activity in specific reading-related regions of the dorsolateral prefrontal cortex. Further research and evaluation are needed to fully understand the implications and potential applications of these findings.
本研究的主要目的是初步探究自主神经系统活动对背外侧前额叶皮层的影响。近期研究已探讨了使用侵入性和非侵入性方法调节自主神经活动的途径，但认知任务期间自主神经活动变化对背外侧前额叶皮层的影响尚未得到充分研究。本初步调查的目的是使用微锥贴片，研究迷走神经刺激诱导的阅读任务期间背外侧前额叶皮层的自主神经活动和血氧饱和度变化。
本研究招募了40名发育正常的成年人。我们仔细研究了在两种情况下（有和无微锥贴片刺激）阅读任务期间背外侧前额叶皮层的自主神经系统活动和血氧饱和度变化。
证实了微锥贴片刺激导致背外侧前额叶皮层的大脑激活发生显著变化。此外，分层多元回归分析揭示了微锥贴片刺激期间背外侧前额叶区域与阅读任务相关的血氧饱和度的特定变化。
应该认识到，本研究是一项初步调查，尚无直接的临床应用。然而，我们的结果表明，外部迷走神经刺激引起的自主神经系统活动变化可能会影响背外侧前额叶皮层特定阅读相关区域的活动。需要进一步的研究和评估，以充分理解这些发现的意义和潜在应用。
